CFB Mouse Models

Why Model CFB

Cfb is the mouse ortholog of human CFB and encodes complement factor B, a serine protease zymogen of the alternative complement pathway. Factor B contributes to formation of the alternative-pathway C3 convertase and has been associated with amplification of complement activation.

The alternative pathway, including factor B, is implicated in several complement-mediated diseases, and factor B inhibitors are in clinical use and development. Cfb-deficient mice show impaired alternative-pathway activity.

Model Applications

Humanized CFB models, in which the human protein replaces the mouse counterpart, have been used to evaluate factor B-directed agents in defined experimental settings.

Custom CFB Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Alternative complement pathway inhibition with iptacopan in IgA nephropathy. N Engl J Med. 2024. doi:10.1056/nejmoa2410316
• Woods DE et al. Isolation of cDNA clones for the human complement protein factor B, a class III major histocompatibility complex gene product. Proc Natl Acad Sci U S A. 1982. doi:10.1073/pnas.79.18.5661

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Cfd · C3 · Cfh · Cfp