Conventional / global / constitutive KO
●4 Models Available
READY TO SHIP!
LIVE · SPERM · EMBRYO · IN PRODUCTION
Cfb Conditional Knockout, Humanized, Knockout mouse models
Browse 4 Cfb mouse models including conditional knockout, humanized, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Cfb conditional knockout mouse, Cfb humanized mouse, Cfb knockout mouse. Request a quote within 24 hours.
Why model Cfb
Cfb is the mouse ortholog of human CFB and encodes complement factor B, the catalytic engine of the alternative pathway. The zymogen comprises three complement control protein modules, a von Willebrand factor type A domain that coordinates magnesium, and a chymotrypsin-like serine protease domain; binding to surface-bound C3b or hydrolyzed C3 opens the molecule for factor D cleavage into Ba and Bb, leaving Bb as the proteolytic subunit of the C3bBb convertase that properdin stabilizes and factor H and decay accelerating factor dissociate. Gain-of-function variants such as human D279G and F286L create decay-resistant convertases and cause atypical hemolytic uremic syndrome and C3 glomerulopathy. Nulls are viable with an intact classical pathway, cleanly isolating amplification loop contributions. Introduce patient missense knockins when spontaneous complement-driven renal disease is the goal, hepatocyte-conditional deletion when the source of circulating factor B matters, and humanization when iptacopan class inhibitors are being profiled.
What Cfb mouse models are available?
ingenious targeting laboratory offers 4 distinct Cfb (CFB) catalog mouse models, featuring conditional knockout, standard knockout, and humanized. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Cfb model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cfb allele types
Knockout, conditional, knockin, humanized, and related paths for Cfb (human CFB). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cfb catalog models
4 Cfb lines with QC documentation and technical support. Cfb floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout. Cfb humanized models carry the human gene sequence for translational research.
- Order
Cfb-Flox
CKOCKO
These mice carry loxP sites flanking exon 3-7 of Cfb gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Cfb gene.
In production — inquireCKO 251798 - Order
hCFB
HUTarget-Humanized, Disease Model
The endogenous mouse Cfb gene was replaced by human CFB gene.
LiveHU 2000078 - Order
Cfb-KO(2)
KOKO
The exon 3-7 of Cfb gene was deleted to generate Cfb knockout mouse.
Sperm CryopreservedKO 253208 - Order
Cfb-KO
KOKO
The exon 3-11 of Cfb gene was deleted to generate Cfb knockout mouse.
Embryo CryopreservedKO 241038
Looking for a Cfb mouse model?
We have 4 Cfb models in stock — including Conditional Knockout, Humanized, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cfb Mouse Model Types
A Cfb knockout mouse has the Cfb gene permanently inactivated, enabling loss of function studies. A Cfb conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cfb, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. A Cfb humanized mouse replaces the mouse Cfb gene with the human ortholog for translational research and drug development.
Modifications available
Jump to catalog backed pages for Cfb organized by modification type. Each URL is indexable and matches common search patterns.
Cfb mouse model FAQ
What Cfb Conditional Knockout mouse models are available?
When Cfb Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Cfb knockout embryonic lethal in mice?
It depends on background and allele design. Some Cfb germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Cfb animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Cfb?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ingenious targeting laboratory
Send the Cfb line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.