Dpp4 Mouse Models

Why Model Dpp4

Dpp4 is the mouse ortholog of human DPP4 and encodes dipeptidyl peptidase-4 (CD26), a cell-surface and soluble serine exopeptidase. DPP-4 cleaves several peptides, including the incretin hormones GLP-1 and GIP, and has been associated with regulation of their activity.

DPP-4 inhibitors are used in type 2 diabetes, and DPP-4 has additional roles in immune regulation; in some species DPP-4 serves as a receptor for certain coronaviruses. Dpp4-deficient mice are viable and show altered glucose tolerance and incretin levels.

Model Applications

Humanized DPP4 models, in which the human protein replaces the mouse counterpart, have been used to study DPP-4 biology, DPP-4-targeted agents, and human DPP-4-dependent coronavirus infection in defined experimental settings.

Custom Dpp4 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Dipeptidyl peptidase-4 inhibitors: a systematic review of structure-activity relationship studies. Iran J Pharm Res. 2024. doi:10.5812/ijpr-151581
• Misumi Y et al. Molecular cloning and sequence analysis of human dipeptidyl peptidase IV, a serine proteinase on the cell surface. Biochim Biophys Acta. 1992. doi:10.1016/0167-4781(92)90036-y

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Glp1r · Gipr · Fap · Dpp8