Gipr Mouse Models

Why Model Gipr

Gipr is the mouse ortholog of human GIPR and encodes the glucose-dependent insulinotropic polypeptide (GIP) receptor, a class B G-protein-coupled receptor. GIP-receptor signaling has been associated with glucose-dependent insulin secretion and with effects on adipose tissue and energy metabolism.

The GIP receptor is a component of dual GIP/GLP-1 receptor agonists used in type 2 diabetes and obesity, and its pharmacology is an active area of research. Gipr-deficient mice are viable and show altered responses to nutrient loading and to diet-induced obesity.

Model Applications

Humanized GIPR models, in which the human receptor replaces the mouse counterpart, have been used to evaluate GIP-receptor-targeted and dual-incretin agents in vivo.

Gipr models have been used to study incretin biology in defined experimental settings.

Custom Gipr Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Tirzepatide against obesity and insulin-resistance: pathophysiological aspects and clinical evidence. Front Endocrinol. 2024. doi:10.3389/fendo.2024.1402583
• Usdin TB et al. Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain. Endocrinology. 1993. doi:10.1210/endo.133.6.8243312

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Glp1r · Gcgr · Dpp4 · Gip