Conventional / global / constitutive KO
●2 Models Available
Egfr Conditional Knockout, Knockout mouse models
Browse 2 Egfr mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Egfr conditional knockout mouse, Egfr knockout mouse. Contact us for availability and fast turnaround.
Why model Egfr
Egfr, the mouse ortholog of human EGFR, encodes ERBB1, a receptor tyrosine kinase whose extracellular domains I through IV adopt a tethered autoinhibited conformation until ligand binding to domains I and III exposes the domain II dimerization arm, permitting formation of an asymmetric kinase dimer in which one lobe allosterically activates the other, with autophosphorylated C-terminal tyrosines recruiting GRB2, SHC and PLC gamma to fire RAS-MAPK and PI3K-AKT. Oncogenic exon 19 deletions and L858R destabilize the inactive kinase conformation and confer TKI sensitivity, T790M and C797S confer resistance, and the vIII extracellular truncation drives glioblastoma. Critically, mouse Egfr is not bound by cetuximab and differs in domain III epitopes, so ectodomain humanization is mandatory for antibody and antibody-drug conjugate testing, while inducible mutant knockins model TKI response. Germline nulls die perinatally with strain-dependent severity, so conditional alleles plus a lineage Cre are required for adult skin, intestinal or lung studies.
What Egfr mouse models are available?
ingenious targeting laboratory offers 2 distinct Egfr (EGFR) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Egfr model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Egfr allele types
Knockout, conditional, knockin, humanized, and related paths for Egfr (human EGFR). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Egfr catalog models
2 Egfr lines with QC documentation and technical support. Egfr floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Egfr (EGFR) from ITL supported projects.
- Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcriptionWan H, Lapek J, Fujimura K, Strnadel J, Liu B, Gonzalez DJ, Zhang W, Watson F, Yu V, Liu C, Melo CM, Miller YI, Elliott KC, Cheresh DA, Klemke RL. (2018). Cell Discov 4(1): 26
Looking for a Egfr mouse model?
We have 2 Egfr models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Egfr Mouse Model Types
A Egfr knockout mouse has the Egfr gene permanently inactivated, enabling loss of function studies. A Egfr conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Egfr, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Egfr organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Egfr.