FCER1A Mouse Models

Why Model FCER1A

Fcer1a is the mouse ortholog of human FCER1A and encodes the alpha subunit of the high-affinity IgE receptor (FcεRI), which binds immunoglobulin E. The alpha subunit has been associated with IgE binding, and the receptor complex signals in mast cells and basophils.

FcεRI is central to IgE-mediated allergic responses, and the IgE pathway is targeted therapeutically. Fcer1a-deficient mice show loss of IgE-mediated mast-cell responses.

Model Applications

Humanized FCER1A models, in which the human subunit replaces the mouse counterpart, have been used to study IgE-mediated responses and to evaluate agents targeting the IgE pathway in defined experimental settings.

Custom FCER1A Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Structural insights into the high-affinity IgE receptor FcεRI complex. Nature. 2024. doi:10.1038/s41586-024-07864-5
• Kochan J et al. Isolation of the gene coding for the alpha subunit of the human high affinity IgE receptor. Nucleic Acids Res. 1988. doi:10.1093/nar/16.8.3584

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Fcer1g · Ms4a2 · Fcer2 · Il4