Gcgr Mouse Models

Why Model Gcgr

Gcgr is the mouse ortholog of human GCGR and encodes the glucagon receptor, a class B G-protein-coupled receptor expressed mainly in liver and kidney. Glucagon-receptor signaling, primarily through Gs and cAMP, has been associated with hepatic glucose production and lipid metabolism.

Glucagon-receptor agonism is a component of GLP-1/glucagon dual agonists under study for obesity and metabolic liver disease, and glucagon-receptor antagonism has been explored for diabetes. Gcgr-deficient mice are viable and show low blood glucose and pancreatic islet changes.

Model Applications

Humanized GCGR models, in which the human receptor replaces the mouse counterpart, have been used to evaluate glucagon-receptor-targeted and dual-agonist agents in vivo.

Gcgr models have been used to study glucagon signaling in metabolism in defined experimental settings.

Custom Gcgr Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Effect of survodutide, a glucagon and GLP-1 receptor dual agonist, on weight loss: a systematic review and meta-analysis. Diabetol Metab Syndr. 2024. doi:10.1186/s13098-024-01501-x
• Jelinek LJ et al. Expression cloning and signaling properties of the rat glucagon receptor. Science. 1993. doi:10.1126/science.8384375

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Glp1r · Gipr · Gcg · Ins2