IL12B Mouse Models

Why Model IL12B

Il12b is the mouse ortholog of human IL12B and encodes the p40 subunit shared by interleukin-12 and interleukin-23. The p40 subunit pairs with p35 to form IL-12 and with p19 to form IL-23, cytokines that have been associated with Th1 and Th17 responses.

The shared p40 subunit is targeted by antibodies used in psoriasis and inflammatory bowel disease. Il12b-deficient mice show impaired IL-12- and IL-23-dependent responses.

Model Applications

Humanized IL12B models, in which the human subunit replaces the mouse counterpart, have been used to evaluate p40-directed biologics in defined experimental settings.

Custom IL12B Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Risankizumab versus ustekinumab for moderate-to-severe Crohn’s disease. N Engl J Med. 2024. doi:10.1056/nejmoa2314585
• Gubler U et al. Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc Natl Acad Sci U S A. 1991. doi:10.1073/pnas.88.10.4143

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Il12a · Il23a · Il12rb1 · Il12rb2