Il23a Mouse Models

Why Model Il23a

Il23a is the mouse ortholog of human IL23A and encodes the p19 subunit of interleukin-23, which pairs with the p40 subunit (shared with IL-12) to form IL-23. IL-23 signals through a receptor complex and has been associated with maintenance and function of Th17 and other IL-17-producing cells.

IL-23 is implicated in psoriasis and other chronic inflammatory diseases, and antibodies targeting IL-23 (p19) or the shared p40 subunit are used clinically. Il23a-deficient mice are viable and show reduced Th17-associated inflammation in disease models.

Model Applications

Il23a knockout mice have been used to study IL-23-dependent inflammation. Humanized IL23A models, sometimes paired with IL-12B/p40 humanization, have been used to evaluate IL-23-targeted biologics in defined experimental settings.

Custom Il23a Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• IL-23 inhibition for chronic inflammatory disease. Lancet. 2024. doi:10.1016/S0140-6736(24)01750-1
• Cua DJ et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature. 2003. doi:10.1038/nature01355
• Oppmann B et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000. doi:10.1016/s1074-7613(00)00070-4

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Il12b · Il23r · Il17a · Il12a