Conventional / global / constitutive KO
●5 Models Available
Il17a Conditional Knockout, Knockin, Knockout mouse models
Browse 5 Il17a mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Il17a conditional knockout mouse, Il17a knockin mouse, Il17a knockout mouse. Request a quote within 24 hours.
Why model Il17a
Il17a is the mouse ortholog of human IL17A and encodes a cystine-knot cytokine acting as a homodimer, and also as a heterodimer with interleukin 17F, on the IL-17RA and IL-17RC receptor complex, recruiting the adaptor Act1 encoded by Traf3ip2 plus TRAF6 to activate NF-kB, MAPK signaling, and transcript stabilization of CXCL1, CXCL2, CSF3, and antimicrobial peptides in epithelium and stroma. Producers are RORgt dependent Th17 cells, gamma delta T17 cells, ILC3s, and MAIT cells, and human IL17RA or IL17F lesions cause chronic mucocutaneous candidiasis while excess drives psoriasis, the indication where secukinumab and ixekizumab succeeded. Because Il17a and Il17f are adjacent and coregulated, single nulls give partial phenotypes and heterodimer contributions are missed, so compound alleles or receptor deletion are frequently required. Fate mapping alleles such as Il17a-Cre distinguish current from historical expression, and conditional deletion in gamma delta versus CD4 compartments is what actually assigns the pathogenic source.
What Il17a mouse models are available?
ingenious targeting laboratory offers 5 distinct Il17a (IL17A) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 5 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Il17a model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Il17a allele types
Knockout, conditional, knockin, humanized, and related paths for Il17a (human IL17A). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Il17a catalog models
5 Il17a lines with QC documentation and technical support. Il17a floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Il17a-Flox
Conditional KnockoutKO/CKO mice
sperm cryopreservationCKO 230191 - Order
Il17a-Cre
KnockinCre/Dre Toolbox of Mice
liveKI 200137 - Order
Il17a-2A-CreERT2
KnockinCre/Dre Toolbox of Mice
embryo cryopreservationKI 00059 - Order
Il17a-KO(2)
KnockoutKO/CKO mice
sperm cryopreservationKO 251195 - Order
Il17a-KO
KnockoutKO/CKO mice, disease model mice
embryo cryopreservationKO 00131
Looking for a Il17a mouse model?
We have 5 Il17a models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model5
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Il17a Mouse Model Types
A Il17a knockout mouse has the Il17a gene permanently inactivated, enabling loss of function studies. A Il17a conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Il17a, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Il17a knockin models carry a precisely inserted sequence at the Il17a locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Il17a organized by modification type. Each URL is indexable and matches common search patterns.