IL18 Mouse Models

Why Model IL18

Il18 is the mouse ortholog of human IL18 and encodes interleukin-18, an IL-1-family cytokine that, like IL-1β, is processed from a precursor. IL-18 signals through its receptor and has been associated with promotion of interferon-gamma production and regulation of innate and adaptive immunity.

IL-18 is implicated in autoinflammatory and other immune-mediated conditions, and IL-18-pathway-directed approaches are under study; IL-18 binding protein regulates its activity. Il18-deficient mice are viable with altered interferon-gamma responses.

Model Applications

Humanized IL18 models, in which the human cytokine replaces the mouse counterpart, have been used to evaluate IL-18-pathway-directed agents in defined experimental settings.

Custom IL18 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Associations between circulating interleukin-18 levels and adult-onset Still’s disease: a meta-analysis. J Rheum Dis. 2024. doi:10.4078/jrd.2024.0095
• Okamura H et al. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature. 1995. doi:10.1038/378088a0

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Il18bp · Il18r1 · Il1b · Ifng