Conventional / global / constitutive KO
●4 Models Available
READY TO SHIP!
LIVE · SPERM
Il18 Conditional Knockout, Knockin, Knockout mouse models
Browse 4 Il18 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Il18 conditional knockout mouse, Il18 knockin mouse, Il18 knockout mouse. Request a quote within 24 hours.
Why model Il18
Il18 encodes interleukin 18, the mouse ortholog of human IL18 and an interleukin 1 family member synthesized as an inactive precursor constitutively stockpiled in epithelium, keratinocytes, and macrophages, then cleaved by caspase-1 downstream of NLRP3 or NLRC4 inflammasomes, or by caspase-8, neutrophil proteases, and granzyme B, before release through gasdermin D pores. Mature cytokine engages IL-18R1 with the accessory chain IL18RAP to recruit MyD88 and IRAK4, driving NF-kB and, together with interleukin 12, potent interferon gamma output from Th1, NK, and ILC1 cells, while the secreted decoy interleukin 18 binding protein sets the free ligand concentration and rises in macrophage activation syndrome. Allele design should follow that regulation: a conditional null tests requirement, an uncleavable precursor knockin isolates processing, and humanization supports both neutralizing antibody and decoy-resistant agonist programs. Because Il18 and Il1b share upstream inflammasome machinery, attribute phenotypes with ligand-specific alleles rather than caspase-1 deletion.
What Il18 mouse models are available?
ingenious targeting laboratory offers 4 distinct Il18 (IL18) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Il18 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Il18 allele types
Knockout, conditional, knockin, humanized, and related paths for Il18 (human IL18). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Il18 catalog models
4 Il18 lines with QC documentation and technical support. Il18 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Il18-Flox
CKOCKO
These strains carry loxP sites flanking exon 3-5 of Il18 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Il18 gene.
Sperm CryopreservedCKO 231326 - Order
Il18-3×FLAG-NLS-mNeongreen-NLS-6×HIS
KIFluorescent Model, Other Toolbox (non-Cre, non-Fluorescent)
The 3×FLAG-NLS-mNeongreen-NLS-6×HIS expression cassette was substituted for the sequence between the start and stop codons of the Il18 gene.
Sperm CryopreservedKI 233874 - Order
Il18-Luc-2A-EGFP
KIFluorescent Model
A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il18.
LiveKI 00032 - Order
Il18-KO
KOKO
Exon 3-5 of Il18 gene was deleted to generate Il18 knockout mice.
Sperm CryopreservedKO 190469
Looking for a Il18 mouse model?
We have 4 Il18 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Il18 Mouse Model Types
A Il18 knockout mouse has the Il18 gene permanently inactivated, enabling loss of function studies. A Il18 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Il18, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Il18 knockin models carry a precisely inserted sequence at the Il18 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Il18 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Il18 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.