IL1B Mouse Models

Why Model IL1B

Il1b is the mouse ortholog of human IL1B and encodes interleukin-1 beta, an IL-1-family cytokine produced largely by myeloid cells. IL-1β is generated from a precursor by inflammasome-associated processing and has been associated with promotion of inflammation and fever.

IL-1β is implicated in a range of inflammatory and autoinflammatory conditions, and IL-1β-directed agents are in clinical use. Il1b-deficient mice are viable and show reduced inflammatory responses in several models.

Model Applications

Humanized IL1B models, in which the human cytokine replaces the mouse counterpart, have been used to evaluate IL-1β-directed agents in defined experimental settings.

Il1b knockout mice have been used to study inflammation.

Custom IL1B Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Safety and efficacy of canakinumab for the prevention and control of type 2 diabetes mellitus and its complications: a systematic review. Cureus. 2024. doi:10.7759/cureus.67065
• March CJ et al. Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature. 1985. doi:10.1038/315641a0

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Il1a · Il1rn · Il18 · Nlrp3