Conventional / global / constitutive KO
●4 Models Available
Il1b Conditional Knockout, Knockin, Knockout mouse models
Browse 4 Il1b mouse models including conditional knockout, knockin, knockout variants from ingenious targeting laboratory. Available as Il1b conditional knockout mouse, Il1b knockin mouse, Il1b knockout mouse. Contact us for availability and fast turnaround.
Why model Il1b
Interleukin 1 beta, encoded by the mouse ortholog of human IL1B, is transcribed as an inactive 31 kDa precursor whose maturation requires cleavage at Asp116 by caspase-1 assembled on NLRP3, NLRC4, AIM2, or pyrin inflammasomes, with caspase-8 and neutrophil elastase providing inflammasome independent routes, and export depends on gasdermin D pores rather than the classical secretory pathway. Mature ligand engages IL-1R1 with IL1RAP, recruits MyD88 and IRAK4, and drives NF-kB dependent fever, neutrophil recruitment, interleukin 6 induction, and Th17 support, the axis blocked clinically by canakinumab and anakinra and hyperactivated in cryopyrin associated periodic syndromes. Allele forks are unusually clean: conditional null for requirement, cleavage-resistant knockin to separate transcription from processing, reporter alleles to time inflammasome activity in vivo, and humanization for antibody pharmacology. Because interleukin 1 alpha signals through the same receptor, attribute phenotypes with Il1a comparison rather than assuming Il1r1 readouts reflect interleukin 1 beta alone.
What Il1b mouse models are available?
ingenious targeting laboratory offers 4 distinct Il1b (IL1B) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Il1b model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Il1b allele types
Knockout, conditional, knockin, humanized, and related paths for Il1b (human IL1B). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Il1b catalog models
4 Il1b lines with QC documentation and technical support. Il1b floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Il1b mouse model?
We have 4 Il1b models available — including Conditional Knockout, Knockin, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Il1b Mouse Model Types
A Il1b knockout mouse has the Il1b gene permanently inactivated, enabling loss of function studies. A Il1b conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Il1b, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Il1b knockin models carry a precisely inserted sequence at the Il1b locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Il1b organized by modification type. Each URL is indexable and matches common search patterns.