Lag3 Mouse Models

Why Model Lag3

Lag3 is the mouse ortholog of human LAG3 and encodes LAG-3 (CD223), an inhibitory receptor expressed on activated T cells and other lymphocytes. LAG-3 binds ligands including MHC class II and has been associated with negative regulation of T-cell responses.

LAG-3 is a target of cancer immunotherapy, and an anti-LAG-3 antibody is approved in combination with PD-1 blockade for melanoma. Lag3-deficient mice are viable and show altered T-cell regulation in some models.

Model Applications

Humanized LAG3 models, in which the human receptor replaces the mouse counterpart, have been used to evaluate anti-LAG-3 therapeutics, including in combination with PD-1-targeted agents, in immunocompetent mice.

Lag3 knockout mice have been used to study its role in T-cell regulation.

Custom Lag3 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Immune checkpoint inhibitors: breakthroughs in cancer treatment. 2024. doi:10.20892/j.issn.2095-3941.2024.0055
• Workman CJ, Vignali DAA. Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223). J Immunol. 2005. doi:10.4049/jimmunol.174.2.688
• Triebel F et al. LAG-3, a novel lymphocyte activation gene closely related to CD4. J Exp Med. 1990. doi:10.1084/jem.171.5.1393

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Pdcd1 · Havcr2 · Tigit · Ctla4