Conventional / global / constitutive KO
●2 Models Available
Lag3 Conditional Knockout, Knockout mouse models
Browse 2 Lag3 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Lag3 conditional knockout mouse, Lag3 knockout mouse. Request a quote within 24 hours.
Why model Lag3
Lag3, the mouse ortholog of human LAG3, encodes a CD4 related type I membrane protein with four immunoglobulin superfamily domains, a distinctive extra loop in domain D1 that mediates high-affinity MHC class II binding, and additional reported ligands including fibrinogen like protein 1 and alpha-synuclein fibrils. Inhibitory output depends on the cytoplasmic FSAL motif and a glutamate proline repeat rather than classical ITIMs, and requires cis association with the T cell receptor complex, so LAG-3 dampens signaling by competing for peptide MHC class II and disrupting CD4 dependent assembly rather than by recruiting a canonical phosphatase. Alone, Lag3 nulls show mild phenotypes, but combined loss with Pdcd1 produces rapid lethal autoimmunity including myocarditis on permissive backgrounds, the genetic counterpart of relatlimab plus nivolumab synergy in melanoma. Choose humanization for antibody pharmacology because clinical reagents do not cross-react, and conditional deletion with Cd8-Cre when cell intrinsic exhaustion is the question.
What Lag3 mouse models are available?
ingenious targeting laboratory offers 2 distinct Lag3 (LAG3) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Lag3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Lag3 allele types
Knockout, conditional, knockin, humanized, and related paths for Lag3 (human LAG3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Looking for a Lag3 mouse model?
We have 2 Lag3 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Lag3 Mouse Model Types
A Lag3 knockout mouse has the Lag3 gene permanently inactivated, enabling loss of function studies. A Lag3 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Lag3, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Lag3 organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Lag3.