Pdcd1 Mouse Models

Why Model Pdcd1

Pdcd1 is the mouse ortholog of human PDCD1 and encodes PD-1 (CD279), an inhibitory immunoreceptor expressed on activated T cells and other immune cells. Engagement of PD-1 by its ligands PD-L1 and PD-L2 delivers signals that attenuate T-cell receptor signaling and have been associated with limiting T-cell responses and maintaining peripheral tolerance.

Blockade of the PD-1 pathway can enhance anti-tumor T-cell responses, and anti-PD-1 antibodies are approved for several cancers; responses vary by tumor type and context. Pdcd1-deficient mice are viable and, depending on genetic background, can develop autoimmune features, consistent with a role in immune regulation.

Model Applications

Pdcd1 knockout mice have been used to study immune regulation and autoimmunity. Humanized PDCD1 models, in which the human receptor replaces the mouse counterpart, have been used to evaluate anti-PD-1 antibody therapeutics in immunocompetent mice.

Compound humanized models combining PDCD1 with other checkpoint targets have been used to study combination immunotherapy in defined experimental settings.

Custom Pdcd1 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Regulatory mechanisms of PD-1/PD-L1 in cancers. Mol Cancer. 2024. doi:10.1186/s12943-024-02023-w
• Nishimura H et al. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity. 1999. doi:10.1016/s1074-7613(00)80089-8
• Ishida Y et al. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 1992. doi:10.1002/j.1460-2075.1992.tb05481.x

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Cd274 · Pdcd1lg2 · Ctla4 · Lag3