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Mouse Model Strategies & Allele Types

Rescue Allele / Complementation

A genetic construct introduced to restore the normal function of a gene that has been disrupted, deleted, or mutated. Complementation confirms that an observed phenotype results directly from loss of that gene's function.

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Overview

A rescue allele is a genetic construct introduced to restore the normal function of a gene that has been disrupted, deleted, or mutated. The process of complementation confirms that an observed phenotype results directly from loss of that gene's function.

Frequently Asked Questions

What is the purpose of a rescue allele?

Rescue alleles are designed to test whether a specific phenotype results directly from loss of a particular gene's function by reintroducing functional gene copies.

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Related Terms

Knockout (KO) Mouse Models

A genetically engineered mouse in which a specific gene has been permanently inactivated ('knocked out') to study its biological function, role in disease, and potential as a therapeutic target.

Humanized Mouse Models

A genetically engineered mouse in which one or more human genes, immune system components, or biological pathways have been introduced to replicate aspects of human physiology, bridging the gap between basic research and clinical translation.

Safe Harbor Locus

A defined region of the genome where a transgene or targeted DNA sequence can be inserted without disrupting endogenous genes or regulatory networks. Integration at a safe harbor site allows stable, predictable expression.

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