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Acvr1 Conditional Knockout mouse models
Acvr1, the mouse ortholog of human ACVR1, encodes ALK2, a type I BMP receptor serine/threonine kinase whose glycine-serine rich juxtamembrane box is held in check by FKBP12 until a type II receptor phosphorylates it, releasing kinase activity toward SMAD1, SMAD5 and SMAD8. Recurrent residue changes such as R206H and G328E destabilize the GS domain and confer neomorphic responsiveness to activin A, converting a normally antagonist ligand into an agonist, the mechanism underlying fibrodysplasia ossificans progressiva and diffuse midline glioma. Allele strategy therefore splits cleanly: conditional null alleles interrogate requirement for BMP flux in a given lineage, while conditional knockin of the human disease codon reproduces heterotopic ossification and permits testing of ALK2 kinase inhibitors and activin A blocking antibodies. Germline deletion arrests development at gastrulation, so floxed exons plus an inducible Cre remain mandatory. Paralogous Acvr1b, Bmpr1a and Bmpr1b buffer single-locus loss, making compound conditional genetics worth planning before phenotyping begins.
Tissue restricted knockout of Acvr1 keeps wild type function everywhere else. Breeding is often more robust, and the setup mirrors patient biology where mutations arise in a subset of cells.
What Acvr1 Conditional Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Acvr1 conditional knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Acvr1-Flox | CKO | CKO | IN PRODUCTION | CKO 262597 | Inquire |
| These mice carry loxP sites flanking exon 7 of Acvr1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Acvr1 gene. | |||||
Why this approach
Conditional knockout focuses the experiment on your target tissue while the rest of the animal keeps a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
Pricing and quotes
The Acvr1 Conditional Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Acvr1 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Acvr1 Conditional Knockout mouse models are available?
When Acvr1 Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Acvr1 knockout embryonic lethal in mice?
It depends on background and allele design. Some Acvr1 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Acvr1 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Acvr1?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ITL
Send the Acvr1 Conditional Knockout line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.