Conventional / global / constitutive KO
●1 Model Available
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IN PRODUCTION
Acvr1 Conditional Knockout mouse model
Browse 1 Acvr1 mouse model including conditional knockout variants — in stock and ready to ship from ingenious targeting laboratory. Request a quote within 24 hours.
Why model Acvr1
Acvr1, the mouse ortholog of human ACVR1, encodes ALK2, a type I BMP receptor serine/threonine kinase whose glycine-serine rich juxtamembrane box is held in check by FKBP12 until a type II receptor phosphorylates it, releasing kinase activity toward SMAD1, SMAD5 and SMAD8. Recurrent residue changes such as R206H and G328E destabilize the GS domain and confer neomorphic responsiveness to activin A, converting a normally antagonist ligand into an agonist, the mechanism underlying fibrodysplasia ossificans progressiva and diffuse midline glioma. Allele strategy therefore splits cleanly: conditional null alleles interrogate requirement for BMP flux in a given lineage, while conditional knockin of the human disease codon reproduces heterotopic ossification and permits testing of ALK2 kinase inhibitors and activin A blocking antibodies. Germline deletion arrests development at gastrulation, so floxed exons plus an inducible Cre remain mandatory. Paralogous Acvr1b, Bmpr1a and Bmpr1b buffer single-locus loss, making compound conditional genetics worth planning before phenotyping begins.
What Acvr1 mouse models are available?
ingenious targeting laboratory offers 1 distinct Acvr1 (ACVR1) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Acvr1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Acvr1 allele types
Knockout, conditional, knockin, humanized, and related paths for Acvr1 (human ACVR1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Acvr1 catalog models
1 Acvr1 line with QC documentation and technical support. Acvr1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Acvr1-Flox
CKOCKO
These mice carry loxP sites flanking exon 7 of Acvr1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Acvr1 gene.
In production — inquireCKO 262597
Looking for a Acvr1 mouse model?
We have 1 Acvr1 model in stock — including Conditional Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Acvr1 Mouse Model Types
A Acvr1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Acvr1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Acvr1 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Acvr1 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.