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Adipoq Conditional Knockout mouse models
Adipoq is the mouse ortholog of human ADIPOQ and encodes adiponectin, an adipocyte-secreted protein built from an amino-terminal collagen-like stalk and a carboxy-terminal C1q-like globular head that assembles into trimers, hexamers and high molecular weight oligomers, with the high molecular weight species carrying most insulin-sensitizing activity through Adipor1, Adipor2 and T-cadherin, activating AMPK and ceramidase pathways. Because bioactivity depends on oligomeric state rather than total protein, assays that measure only bulk levels can miss the relevant defect. Null mice show diet-induced insulin resistance with a modest chow phenotype, while knockins that block multimerization separate assembly from secretion, and humanized alleles support agonist and antibody pharmacology. Note that the widely used Adipoq-Cre driver is a knockin at this locus, so verify whether your line perturbs adiponectin dosage before attributing phenotypes to the floxed gene. Read out high molecular weight ELISA, hyperinsulinemic euglycemic clamp, and hepatic lipid content.
Adipoq conditional knockout mice carry a floxed allele so you delete function only where Cre is active. The germline allele stays intact until you cross to a tissue specific Cre. Labs reach for this design when a global knockout is lethal, when they need adult onset loss, or when regional redundancy hides a whole body phenotype.
What Adipoq Conditional Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Adipoq conditional knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Adipoq-Flox | CKO | CKO | DEVELOPING | CKO 261434 | Inquire |
| These mice carry loxP sites flanking exon2 of Adipoq gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Adipoq gene. | |||||
Why this approach
Conditional knockout focuses the experiment on your target tissue while the rest of the animal keeps a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
Pricing and quotes
The Adipoq Conditional Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Adipoq allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Adipoq Conditional Knockout mouse models are available?
When Adipoq Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Adipoq knockout embryonic lethal in mice?
It depends on background and allele design. Some Adipoq germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Adipoq animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Adipoq?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ingenious targeting laboratory
Send the Adipoq Conditional Knockout line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.