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Aldoa Xenograft-Applicable mouse models
Aldoa encodes the mouse ortholog of human ALDOA, the class I fructose-bisphosphate aldolase that assembles into a homotetramer and cleaves fructose-1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate through a Schiff base intermediate formed on an active site lysine. Aldolase A carries most glycolytic flux in skeletal muscle and erythrocytes, and it also binds filamentous actin, WASP family proteins, and the V-ATPase, so loss perturbs cytoskeletal and vesicular biology alongside ATP supply. Recessive human variants produce nonspherocytic hemolytic anemia with rhabdomyolysis, which argues for point knockins rather than deletion when disease fidelity is the goal. Because Aldob and Aldoc are catalytically competent paralogs with overlapping tissue windows, single locus deletion can be buffered wherever they are co-expressed, so compound alleles belong in the plan early. Conditional floxed alleles crossed to Ckmm-Cre, Vav-Cre, or Rosa26-CreER assign glycolytic dependence to muscle, erythroid, or adult tissues while you read lactate output, ATP content, and myopathy endpoints.
Baseline Aldoa loss or humanization may change engraftment. Pilot cohorts de risk larger studies.
What Aldoa Xenograft-Applicable mouse models are available?
ingenious targeting laboratory offers 2 distinct Aldoa xenograft-applicable catalog mouse models. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Aldoa-Flox/Lyz2-2A-CreERT2 | XA | CKO, Cre/Dre Toolbox | SPERM | XA 260953 | Inquire |
| The Aldoa-Flox (CKO 231797) was crossed with Lyz2-2A-CreERT2(KI 18018) to generate Aldoa-Flox/Lyz2-2A-CreERT2 mice. | |||||
| Aldoa-Flox/Shh-EGFP-Cre | XA | CKO, Cre/Dre Toolbox, Fluorescent Model | DEVELOPING | XA 251823 | Inquire |
| The Aldoa-Flox (CKO 231797) was crossed with Shh-EGFP-Cre(KI 200232) to generate Aldoa-Flox/Shh-EGFP-Cre mice. | |||||
Why this approach
We help teams pick alleles that match the experimental question, the organ system, and future breeding plans. For your target tissue centric work, Cre specificity, flox placement, and baseline controls matter as much as the gene edit itself.
Pricing and quotes
The Aldoa Xenograft-Applicable lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Aldoa allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Aldoa Xenograft-Applicable mouse models are available?
When Aldoa Xenograft-Applicable lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Aldoa knockout embryonic lethal in mice?
It depends on background and allele design. Some Aldoa germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Aldoa animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Aldoa?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ITL
Send the Aldoa Xenograft-Applicable line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.