Conventional / global / constitutive KO
●4 Models Available
READY TO SHIP!
SPERM · DEVELOPING
Aldoa Conditional Knockout, Knockout, Xenograft-Applicable mouse models
Browse 4 Aldoa mouse models including conditional knockout, knockout, xenograft-applicable variants from ingenious targeting laboratory. Available as Aldoa conditional knockout mouse, Aldoa knockout mouse, Aldoa xenograft-applicable mouse. Contact us for availability and fast turnaround.
Why model Aldoa
Aldoa encodes the mouse ortholog of human ALDOA, the class I fructose-bisphosphate aldolase that assembles into a homotetramer and cleaves fructose-1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate through a Schiff base intermediate formed on an active site lysine. Aldolase A carries most glycolytic flux in skeletal muscle and erythrocytes, and it also binds filamentous actin, WASP family proteins, and the V-ATPase, so loss perturbs cytoskeletal and vesicular biology alongside ATP supply. Recessive human variants produce nonspherocytic hemolytic anemia with rhabdomyolysis, which argues for point knockins rather than deletion when disease fidelity is the goal. Because Aldob and Aldoc are catalytically competent paralogs with overlapping tissue windows, single locus deletion can be buffered wherever they are co-expressed, so compound alleles belong in the plan early. Conditional floxed alleles crossed to Ckmm-Cre, Vav-Cre, or Rosa26-CreER assign glycolytic dependence to muscle, erythroid, or adult tissues while you read lactate output, ATP content, and myopathy endpoints.
What Aldoa mouse models are available?
ingenious targeting laboratory offers 4 distinct Aldoa (ALDOA) catalog mouse models, featuring conditional knockout, standard knockout, and xenograft applicable lines. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
Aldoa model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Aldoa allele types
Knockout, conditional, knockin, humanized, and related paths for Aldoa (human ALDOA). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Aldoa catalog models
4 Aldoa lines with QC documentation and technical support. Aldoa floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Aldoa-Flox
CKOCKO
These strains carry loxP sites flanking exon 5-10 of Aldoa gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Aldoa gene.
Sperm CryopreservedCKO 231797 - Order
Aldoa-KO
KOKO
exon 5-10 of Aldoa gene was deleted to generate Aldoa knockout mice.
Sperm CryopreservedKO 226330 - Order
Aldoa-Flox/Lyz2-2A-CreERT2
XACKO, Cre/Dre Toolbox
The Aldoa-Flox (CKO 231797) was crossed with Lyz2-2A-CreERT2(KI 18018) to generate Aldoa-Flox/Lyz2-2A-CreERT2 mice.
Sperm CryopreservedXA 260953 - Order
Aldoa-Flox/Shh-EGFP-Cre
XACKO, Cre/Dre Toolbox, Fluorescent Model
The Aldoa-Flox (CKO 231797) was crossed with Shh-EGFP-Cre(KI 200232) to generate Aldoa-Flox/Shh-EGFP-Cre mice.
In DevelopmentXA 251823
Looking for a Aldoa mouse model?
We have 4 Aldoa models available — including Conditional Knockout, Knockout, Xenograft-Applicable types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Aldoa Mouse Model Types
A Aldoa knockout mouse has the Aldoa gene permanently inactivated, enabling loss of function studies. A Aldoa conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Aldoa, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Aldoa organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Aldoa line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.