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Aldoc Conditional Knockout mouse models
Aldoc, ortholog of human ALDOC, encodes aldolase C, the brain enriched class I aldolase known to neuroanatomists as zebrin II because its expression marks alternating parasagittal Purkinje cell stripes across the cerebellum. Catalysis follows the same lysine Schiff base chemistry used by aldolases A and B, splitting fructose-1,6-bisphosphate, but tissue distribution favors neurons and astrocytes, where glycolytic and shuttle flux support neurotransmission. Because aldolase C is a faithful compartment marker as well as an enzyme, a knockin reporter or Cre cassette at the locus buys lineage and stripe resolution that simple deletion cannot, while a conditional null asks whether neuronal glycolysis genuinely requires this isoform. Co-expressed Aldoa carries substantial flux in brain, so anticipate masked phenotypes and consider Aldoa Aldoc compound conditionals. Align the allele with the readout, whether cerebellar patterning, astrocyte lactate export, or glycolytic dependence in glioma models, and select an inducible Cre that spares developmental patterning.
Tissue restricted knockout of Aldoc keeps wild type function everywhere else. Breeding is often more robust, and the setup mirrors patient biology where mutations arise in a subset of cells.
What Aldoc Conditional Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Aldoc conditional knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Aldoc-Flox | CKO | CKO | IN PRODUCTION | CKO 253535 | Inquire |
| These mice carry loxP sites flanking exon 2-9 of Aldoc gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Aldoc gene. | |||||
Why this approach
Conditional knockout focuses the experiment on your target tissue while the rest of the animal keeps a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
Pricing and quotes
The Aldoc Conditional Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Aldoc allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Aldoc Conditional Knockout mouse models are available?
When Aldoc Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Aldoc knockout embryonic lethal in mice?
It depends on background and allele design. Some Aldoc germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Aldoc animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Aldoc?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ingenious targeting laboratory
Send the Aldoc Conditional Knockout line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.