Amh Transgenic mouse models
Amh, mouse ortholog of human AMH, encodes anti-Mullerian hormone, a disulfide-linked TGF-beta superfamily dimer secreted by fetal Sertoli cells and postnatal granulosa cells that must be furin-cleaved to release its bioactive C-terminal domain. Signaling proceeds through the dedicated type II receptor AMHR2 paired with type I receptors ALK2, ALK3, or ALK6 to phosphorylate SMAD1, SMAD5, and SMAD8, driving apoptotic regression of the Mullerian duct mesenchyme in males and restraining primordial follicle recruitment and FSH sensitivity in females. Human loss-of-function alleles in AMH or AMHR2 cause persistent Mullerian duct syndrome, and circulating levels index ovarian reserve. Null mice are viable, so conditional deletion is reserved for separating fetal duct regression from adult follicular restraint, while gain-of-function transgenics test ovarian suppression and Leydig differentiation. No other superfamily ligand engages AMHR2, so redundancy is minimal and single-locus phenotypes are interpretable. Humanized alleles matter most when assaying AMH immunoassays or AMHR2-directed biologics.
Random or targeted integration strategies exist for Amh transgenes. Selection depends on expression level, copy number control, and whether you need a defined safe harbor.
What Amh Transgenic mouse models are available?
ingenious targeting laboratory offers 1 distinct Amh transgenic catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Amh-Cre-Tg(NMX) | Transgenic | Cre/Dre Toolbox of Mice, random transgenic mice | embryo cryopreservation | TG 192024 | Inquire |
Why this approach
We help teams pick alleles that match the experimental question, the organ system, and future breeding plans. For your target tissue centric work, Cre specificity, flox placement, and baseline controls matter as much as the gene edit itself.
Pricing and quotes
The Amh Transgenic lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Amh allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Amh Transgenic mouse models are available?
When Amh Transgenic lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Amh knockout embryonic lethal in mice?
It depends on background and allele design. Some Amh germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Amh animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Amh?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.