Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
SPERM · EMBRYO
Amh Knockin, Knockout mouse models
Browse 2 Amh mouse models including knockin, knockout variants from ingenious targeting laboratory. Available as Amh knockin mouse, Amh knockout mouse. Contact us for availability and fast turnaround.
Why model Amh
Amh, mouse ortholog of human AMH, encodes anti-Mullerian hormone, a disulfide-linked TGF-beta superfamily dimer secreted by fetal Sertoli cells and postnatal granulosa cells that must be furin-cleaved to release its bioactive C-terminal domain. Signaling proceeds through the dedicated type II receptor AMHR2 paired with type I receptors ALK2, ALK3, or ALK6 to phosphorylate SMAD1, SMAD5, and SMAD8, driving apoptotic regression of the Mullerian duct mesenchyme in males and restraining primordial follicle recruitment and FSH sensitivity in females. Human loss-of-function alleles in AMH or AMHR2 cause persistent Mullerian duct syndrome, and circulating levels index ovarian reserve. Null mice are viable, so conditional deletion is reserved for separating fetal duct regression from adult follicular restraint, while gain-of-function transgenics test ovarian suppression and Leydig differentiation. No other superfamily ligand engages AMHR2, so redundancy is minimal and single-locus phenotypes are interpretable. Humanized alleles matter most when assaying AMH immunoassays or AMHR2-directed biologics.
What Amh mouse models are available?
ingenious targeting laboratory offers 2 distinct Amh (AMH) catalog mouse models in the BMP/GDF family, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Amh model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Amh allele types
Knockout, conditional, knockin, humanized, and related paths for Amh (human AMH). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Amh catalog models
2 Amh lines with QC documentation and technical support.
Looking for a Amh mouse model?
We have 2 Amh models available — including Knockin, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Amh Mouse Model Types
A Amh knockout mouse has the Amh gene permanently inactivated, enabling loss of function studies. Amh knockin models carry a precisely inserted sequence at the Amh locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Amh organized by modification type. Each URL is indexable and matches common search patterns.
Related Gene Targets
Amh mouse model FAQ
What Amh Knockin mouse models are available?
When Amh Knockin lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Amh knockout embryonic lethal in mice?
It depends on background and allele design. Some Amh germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Amh animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Amh?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ingenious targeting laboratory
Send the Amh line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.