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Arid1a Xenograft-Applicable mouse models
Arid1a encodes BAF250a, the mouse ortholog of human ARID1A and the largest accessory subunit of the canonical BAF chromatin remodeling complex, where its ARID domain contributes non-sequence-specific DNA contact and its C-terminal region docks onto the SMARCA4 ATPase to target enhancer nucleosome eviction. Tumor alleles are overwhelmingly nonsense or frameshift, collapsing accessibility at lineage and differentiation enhancers in ovarian clear cell carcinoma, endometrioid tumors, gastric adenocarcinoma, and hepatocellular carcinoma. Homozygous deletion causes gastrulation-stage embryonic lethality near E6.5, so useful models require conditional flox alleles with tissue-restricted Cre, frequently combined with Pten or Trp53 loss for penetrant tumors. The paralog Arid1b occupies the same BAF slot in mutually exclusive fashion and buffers single-locus loss, which is precisely why ARID1A mutant cells become selectively dependent on ARID1B, EZH2, and ATR. Choose heterozygous or mosaic loss for dosage questions and full conditional deletion when validating synthetic lethal targets.
Work with your strain choice to align human tumor models with the immune profile you need.
What Arid1a Xenograft-Applicable mouse models are available?
ingenious targeting laboratory offers 1 distinct Arid1a xenograft-applicable catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Arid1a-Flox/Ltf-Cre-IRES-tdTomato | XA | CKO, Cre/Dre Toolbox, Fluorescent Model | DEVELOPING | XA 253378 | Inquire |
| The Arid1a-Flox (CKO 200078) was crossed with Ltf-Cre-IRES-tdTomato(KI 200116) to generate Arid1a-Flox/Ltf-Cre-IRES-tdTomato mice. | |||||
Why this approach
We help teams pick alleles that match the experimental question, the organ system, and future breeding plans. For your target tissue centric work, Cre specificity, flox placement, and baseline controls matter as much as the gene edit itself.
Pricing and quotes
The Arid1a Xenograft-Applicable lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Arid1a allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Arid1a Xenograft-Applicable mouse models are available?
When Arid1a Xenograft-Applicable lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Arid1a knockout embryonic lethal in mice?
It depends on background and allele design. Some Arid1a germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Arid1a animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Arid1a?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Related models and routes
Breed this line with ingenious targeting laboratory
Send the Arid1a Xenograft-Applicable line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.