Bmp6 Knockout mouse models
Bmp6, ortholog of human BMP6, encodes the physiological iron sensor ligand of the liver, produced by sinusoidal endothelial cells in proportion to hepatic iron and acting on hepatocyte ALK2 and ALK3 with ACVR2A and the coreceptor hemojuvelin to phosphorylate SMAD1, SMAD5, and SMAD8 and transactivate the Hamp promoter, thereby setting circulating hepcidin and ferroportin-mediated iron export. Human variants reduce hepcidin and contribute to non-HFE iron overload, while pathway blockade underlies anemia of inflammation therapeutics. Nulls are viable with marked hepatic and pancreatic iron loading, so constitutive deletion is informative, though endothelial conditional floxed alleles are needed to prove the cellular source and to avoid confounding skeletal effects. Point knockins disrupting the hemojuvelin-dependent interface separate iron sensing from generic osteogenic signaling. Because BMP2 encoded by Bmp2 also contributes hepatic hepcidin induction and Bmp5 and Bmp7 overlap elsewhere, compound genetics is advisable when the endpoint is complete hepcidin failure rather than partial derepression.
Global Bmp6 deletion answers broad mechanism questions quickly. If timing or site matters, conditional alleles are a natural next step after the null is characterized.
What Bmp6 Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Bmp6 knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Bmp6-KO | Knockout | KO/CKO mice | sperm cryopreservation | KO 190530 | Inquire |
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Bmp6 Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Bmp6 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Bmp6 Knockout mouse models are available?
When Bmp6 Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Bmp6 knockout embryonic lethal in mice?
It depends on background and allele design. Some Bmp6 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Bmp6 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Bmp6?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.