Cdk4 Conditional Knockout mouse — Albumin-Cre pairing
Cdk4 conditional knockout mice carry a floxed allele so you delete function only where Cre recombinase is active. This design keeps the germline allele intact until you cross to a tissue specific Cre. It is often the first choice when a global knockout is lethal, when you need adult onset loss, or when regional redundancy masks a whole body phenotype. For liver work, plan Cre specificity, reporter crosses, and baseline phenotyping before you scale.
Driver pairing
Hepatocyte directed Albumin promoter driven Cre. Widely used for liver specific recombination with minimal reported extrahepatic activity in most Cre reporter studies. Pair with floxed alleles for late stage metabolic and oncology experiments.
Catalog options
Conditional knockout keeps liver as the experimental theater while the rest of the animal retains a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
| Model | Type | Category | Availability | Catalog # | |
|---|---|---|---|---|---|
| Cdk4-Flox | Conditional Knockout | KO/CKO mice | sperm cryopreservation | CKO 232631 | Inquire |
Why this approach
Conditional knockout keeps neuron as the experimental theater while the rest of the animal retains a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
Pricing and quotes
The Cdk4 Conditional Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Cdk4 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with milestones for genotyping, QC, and dispatch.
FAQ
Is Cdk4 knockout embryonic lethal in mice?
Lethality depends on genetic background and exact allele design. Some Cdk4 germline knockouts are viable, others require conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null approaches before you commit.
Which Cre driver is best for albumin cre focused experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak patterns. We map your organ and cell type to a short list of proven Cre lines, then discuss reporter crosses and controls. Your query highlights albumin cre as a primary axis, which we treat as the starting point for driver selection.
Do you ship live Cdk4 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a model generation project with cryo or live dispatch options depending on cohort timing and geography.
How do I request a quote for Cdk4?
Use the catalog inquire buttons or the request quote form with your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.