Conventional / global / constitutive KO
●2 Models Available
Cdk4 Conditional Knockout, Knockout mouse models
Browse 2 Cdk4 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Cdk4 conditional knockout mouse, Cdk4 knockout mouse. Contact us for availability and fast turnaround.
Why model Cdk4
Cdk4, mouse ortholog of human CDK4, encodes the D-cyclin dependent kinase that initiates RB phosphorylation at the restriction point, is directly inhibited by the INK4 proteins p16, p15, p18 and p19 through an allosteric interface that distorts the ATP site, and requires assembly with p21 or p27 plus CAK activation to function. The R24C substitution abolishes INK4 binding and yields an INK4-insensitive kinase, and the homologous human R24C and R24H alleles cause familial melanoma, so an R24C knockin is the appropriate tool for testing whether tumors depend on INK4 restraint or on CDK4/6 inhibitor binding. Null mice are viable but diabetic from beta cell hypoplasia and infertile, making constitutive alleles usable while conditional designs isolate tissue requirement. Cdk6 substitutes broadly, particularly in hematopoietic lineages, so single deletion understates dependency and palbociclib class resistance studies need compound alleles. Select nulls for dependency mapping, R24C knockins for oncogenic drive, and pair conditional alleles with a lineage-matched Cre.
What Cdk4 mouse models are available?
ingenious targeting laboratory offers 2 distinct Cdk4 (CDK4) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Cdk4 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cdk4 allele types
Knockout, conditional, knockin, humanized, and related paths for Cdk4 (human CDK4). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cdk4 catalog models
2 Cdk4 lines with QC documentation and technical support. Cdk4 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Cdk4 mouse model?
We have 2 Cdk4 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cdk4 Mouse Model Types
A Cdk4 knockout mouse has the Cdk4 gene permanently inactivated, enabling loss of function studies. A Cdk4 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cdk4, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Cdk4 organized by modification type. Each URL is indexable and matches common search patterns.