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Cfb Humanized mouse models
Cfb is the mouse ortholog of human CFB and encodes complement factor B, the catalytic engine of the alternative pathway. The zymogen comprises three complement control protein modules, a von Willebrand factor type A domain that coordinates magnesium, and a chymotrypsin-like serine protease domain; binding to surface-bound C3b or hydrolyzed C3 opens the molecule for factor D cleavage into Ba and Bb, leaving Bb as the proteolytic subunit of the C3bBb convertase that properdin stabilizes and factor H and decay accelerating factor dissociate. Gain-of-function variants such as human D279G and F286L create decay-resistant convertases and cause atypical hemolytic uremic syndrome and C3 glomerulopathy. Nulls are viable with an intact classical pathway, cleanly isolating amplification loop contributions. Introduce patient missense knockins when spontaneous complement-driven renal disease is the goal, hepatocyte-conditional deletion when the source of circulating factor B matters, and humanization when iptacopan class inhibitors are being profiled.
Humanized Cfb mice substitute the human ortholog sequence so drug binding sites and pathway feedback match the clinic more closely.
What Cfb Humanized mouse models are available?
ingenious targeting laboratory offers 1 distinct Cfb humanized catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| hCFB | HU | Target-Humanized, Disease Model | LIVE | HU 2000078 | Inquire |
| The endogenous mouse Cfb gene was replaced by human CFB gene. | |||||
Why this approach
Knockin and humanized formats keep regulatory context at the endogenous locus. For your target tissue focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.
Pricing and quotes
The Cfb Humanized lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Cfb allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Cfb Humanized mouse models are available?
When Cfb Humanized lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Cfb knockout embryonic lethal in mice?
It depends on background and allele design. Some Cfb germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Cfb animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Cfb?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Related models and routes
Breed this line with ingenious targeting laboratory
Send the Cfb Humanized line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.