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Cfh Knockin mouse models
Cfh, ortholog of human CFH, encodes factor H, the principal soluble regulator restraining alternative pathway amplification on host surfaces. Its twenty complement control protein modules are functionally partitioned: CCP1 to CCP4 accelerate decay of C3bBb and serve as cofactor for factor I cleavage of C3b, while CCP19 and CCP20 read host surface markers, binding sialic acid, glycosaminoglycans, and C3d simultaneously to localize regulation. Loss of function causes uncontrolled fluid phase C3 consumption, and mouse Cfh nulls develop spontaneous C3 glomerulopathy with dense intramembranous deposits, making this one of few complement models with autonomous renal pathology. Human disease splits sharply by domain: CCP20 mutations and anti-factor H autoantibodies cause atypical hemolytic uremic syndrome, whereas the CCP7 Y402H variant drives age-related macular degeneration. Match allele to question using the null for C3 glomerulopathy, domain-specific knockins for surface recognition, and humanization or Y402H equivalents for ocular endpoints.
Targeting Cfh preserves positional context compared with viral or BAC approaches. That helps when you quantify expression or map chromatin.
What Cfh Knockin mouse models are available?
ingenious targeting laboratory offers 1 distinct Cfh knockin catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Cfh-W1206R | KI | Point Mutation | LIVE | KI 242139 | Inquire |
| These mice carry a W1206R mutation of Cfh gene. | |||||
Why this approach
Knockin and humanized formats keep regulatory context at the endogenous locus. For your target tissue focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.
Pricing and quotes
The Cfh Knockin lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Cfh allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Cfh Knockin mouse models are available?
When Cfh Knockin lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Cfh knockout embryonic lethal in mice?
It depends on background and allele design. Some Cfh germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Cfh animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Cfh?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Related models and routes
Breed this line with ingenious targeting laboratory
Send the Cfh Knockin line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.