Conventional / global / constitutive KO
●5 Models Available
READY TO SHIP!
LIVE · SPERM
Cfh Conditional Knockout, Humanized, Knockin mouse models
Browse 5 Cfh mouse models including conditional knockout, humanized, knockin variants — in stock and ready to ship from ingenious targeting laboratory. Available as Cfh conditional knockout mouse, Cfh humanized mouse, Cfh knockin mouse, Cfh knockout mouse. Request a quote within 24 hours.
Why model Cfh
Cfh, ortholog of human CFH, encodes factor H, the principal soluble regulator restraining alternative pathway amplification on host surfaces. Its twenty complement control protein modules are functionally partitioned: CCP1 to CCP4 accelerate decay of C3bBb and serve as cofactor for factor I cleavage of C3b, while CCP19 and CCP20 read host surface markers, binding sialic acid, glycosaminoglycans, and C3d simultaneously to localize regulation. Loss of function causes uncontrolled fluid phase C3 consumption, and mouse Cfh nulls develop spontaneous C3 glomerulopathy with dense intramembranous deposits, making this one of few complement models with autonomous renal pathology. Human disease splits sharply by domain: CCP20 mutations and anti-factor H autoantibodies cause atypical hemolytic uremic syndrome, whereas the CCP7 Y402H variant drives age-related macular degeneration. Match allele to question using the null for C3 glomerulopathy, domain-specific knockins for surface recognition, and humanization or Y402H equivalents for ocular endpoints.
What Cfh mouse models are available?
ingenious targeting laboratory offers 5 distinct Cfh (CFH) catalog mouse models, featuring conditional knockout, standard knockout, knockin, and humanized. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 5 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Cfh model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cfh allele types
Knockout, conditional, knockin, humanized, and related paths for Cfh (human CFH). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cfh catalog models
5 Cfh lines with QC documentation and technical support. Cfh floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout. Cfh humanized models carry the human gene sequence for translational research.
- Order
Cfh-Flox
CKOCKO
These strains carry loxP sites flanking exon 2-3 of Cfh gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Cfh gene.
Sperm CryopreservedCKO 241281 - Order
hCFH
HUTarget-Humanized
The endogenous mouse Cfh gene was replaced by human CFH gene.
LiveHU 233337 - Order
Cfh-W1206R
KIPoint Mutation
These mice carry a W1206R mutation of Cfh gene.
LiveKI 242139 - Order
Cfh-KO(2)
KOKO
The exon 2-3 of Cfh gene was deleted to generate Cfh knockout mouse.
Sperm CryopreservedKO 251079 - Order
Cfh-KO
KOKO
The exon 2-22 of Cfh gene was deleted to generate Cfh knockout mouse.
LiveKO 232884
Looking for a Cfh mouse model?
We have 5 Cfh models in stock — including Conditional Knockout, Humanized, Knockin types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model5
Models Available
4
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cfh Mouse Model Types
A Cfh knockout mouse has the Cfh gene permanently inactivated, enabling loss of function studies. A Cfh conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cfh, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Cfh knockin models carry a precisely inserted sequence at the Cfh locus, useful for reporter, tag, or humanization studies. A Cfh humanized mouse replaces the mouse Cfh gene with the human ortholog for translational research and drug development.
Modifications available
Jump to catalog backed pages for Cfh organized by modification type. Each URL is indexable and matches common search patterns.
Cfh mouse model FAQ
What Cfh Conditional Knockout mouse models are available?
When Cfh Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Cfh knockout embryonic lethal in mice?
It depends on background and allele design. Some Cfh germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Cfh animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Cfh?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ingenious targeting laboratory
Send the Cfh line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.