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Chchd2 Knockout mouse models
Encoding a twin CX9C intermembrane space protein imported through the MIA40 relay, Chchd2 is the mouse ortholog of human CHCHD2 (PARK22), where it associates with cytochrome c oxidase subunits, contributes to cristae organization together with CHCHD10, and under hypoxia relocates to the nucleus to act on oxygen-responsive promoter elements, giving it both a bioenergetic and a transcriptional identity. Dominant T61I and R145Q substitutions cause autosomal dominant Parkinson disease with α-synuclein pathology, and the mutant protein aggregates and destabilizes the CHCHD2 and CHCHD10 heterodimer rather than simply losing activity. As with its paralog, constitutive nulls display mild or age-delayed phenotypes, so a T61I knockin is the design matched to dopaminergic degeneration endpoints, while a conditional null crossed to Dat-Cre tests whether reduced dosage alone compromises nigral neurons. Because Chchd10 compensates directly through heterodimer formation, plan compound conditional genetics early and quantify mitochondrial integrated stress response markers with nigral cell counts.
Chchd2 null animals are straightforward to genotype and phenotype when survival is acceptable. They remain a standard background for pharmacology, biomarker, and rescue studies.
What Chchd2 Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Chchd2 knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Chchd2-KO | KO | KO | DEVELOPING | KO 263816 | Inquire |
| The exon2 of Chchd2 gene was deleted to generate Chchd2 knockout mouse. | |||||
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Chchd2 Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Chchd2 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Chchd2 Knockout mouse models are available?
When Chchd2 Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Chchd2 knockout embryonic lethal in mice?
It depends on background and allele design. Some Chchd2 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Chchd2 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Chchd2?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ITL
Send the Chchd2 Knockout line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.