Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
DEVELOPING · IN PRODUCTION
Chchd2 Conditional Knockout, Knockout mouse models
Browse 2 Chchd2 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Chchd2 conditional knockout mouse, Chchd2 knockout mouse. Request a quote within 24 hours.
Why model Chchd2
Encoding a twin CX9C intermembrane space protein imported through the MIA40 relay, Chchd2 is the mouse ortholog of human CHCHD2 (PARK22), where it associates with cytochrome c oxidase subunits, contributes to cristae organization together with CHCHD10, and under hypoxia relocates to the nucleus to act on oxygen-responsive promoter elements, giving it both a bioenergetic and a transcriptional identity. Dominant T61I and R145Q substitutions cause autosomal dominant Parkinson disease with α-synuclein pathology, and the mutant protein aggregates and destabilizes the CHCHD2 and CHCHD10 heterodimer rather than simply losing activity. As with its paralog, constitutive nulls display mild or age-delayed phenotypes, so a T61I knockin is the design matched to dopaminergic degeneration endpoints, while a conditional null crossed to Dat-Cre tests whether reduced dosage alone compromises nigral neurons. Because Chchd10 compensates directly through heterodimer formation, plan compound conditional genetics early and quantify mitochondrial integrated stress response markers with nigral cell counts.
What Chchd2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Chchd2 (CHCHD2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Chchd2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Chchd2 allele types
Knockout, conditional, knockin, humanized, and related paths for Chchd2 (human CHCHD2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Chchd2 catalog models
2 Chchd2 lines with QC documentation and technical support. Chchd2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Chchd2-Flox
CKOCKO
These mice carry loxP sites flanking exon2 of Chchd2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Chchd2 gene.
In production — inquireCKO 260701 - Order
Chchd2-KO
KOKO
The exon2 of Chchd2 gene was deleted to generate Chchd2 knockout mouse.
In DevelopmentKO 263816
Looking for a Chchd2 mouse model?
We have 2 Chchd2 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Chchd2 Mouse Model Types
A Chchd2 knockout mouse has the Chchd2 gene permanently inactivated, enabling loss of function studies. A Chchd2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Chchd2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Chchd2 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ITL
Send the Chchd2 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.