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Dlg2 Conditional Knockout mouse models
Encoding PSD-93, also called chapsyn-110, Dlg2 is the mouse ortholog of human DLG2 and a palmitoylated membrane-associated guanylate kinase whose N-terminal cysteines drive raft targeting and whose PDZ1 and PDZ2 domains bind the ESDV motif of GluN2A and GluN2B, clustering NMDA receptors and Kv1 channels at the postsynaptic density while its guanylate kinase domain recruits GKAP and the Shank and Homer scaffold layer. It preferentially stabilizes GluN2A-containing receptors in mature synapses, giving it a developmental profile distinct from SAP102. Rare deletions and exonic copy number variants at the human locus are established risk factors for schizophrenia and intellectual disability, making dosage-sensitive alleles biologically relevant. Constitutive nulls are viable with mild synaptic phenotypes, so a heterozygous or conditional deletion better mirrors human haploinsufficiency, and Camk2a-Cre or interneuron drivers assign circuit contributions. Dlg1, Dlg3 and Dlg4 compensate substantially, so quantify all four paralogs after deletion.
Tissue restricted knockout of Dlg2 keeps wild type function everywhere else. Breeding is often more robust, and the setup mirrors patient biology where mutations arise in a subset of cells.
What Dlg2 Conditional Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Dlg2 conditional knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Dlg2-Flox | CKO | CKO | DEVELOPING | CKO 231891 | Inquire |
| These strains carry loxP sites flanking Exon1 of Dlg2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Dlg2 gene. | |||||
Why this approach
Conditional knockout focuses the experiment on your target tissue while the rest of the animal keeps a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
Pricing and quotes
The Dlg2 Conditional Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Dlg2 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Dlg2 Conditional Knockout mouse models are available?
When Dlg2 Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Dlg2 knockout embryonic lethal in mice?
It depends on background and allele design. Some Dlg2 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Dlg2 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Dlg2?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ITL
Send the Dlg2 Conditional Knockout line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.