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Dll1 Knockout mouse models
Dll1, ortholog of human DLL1, encodes Delta-like 1, a single-pass transmembrane Notch ligand with an N-terminal MNNL and DSL domain plus tandem EGF repeats that engages NOTCH1 and NOTCH2 in trans, and whose activity depends on MIB1-mediated ubiquitination and endocytic pulling force to expose the S2 cleavage site for ADAM10 and gamma-secretase. Oscillatory expression in presomitic mesoderm couples the segmentation clock to somite boundary formation, and the ligand also governs neural progenitor lateral inhibition, muscle progenitor maintenance, and intestinal secretory fate. Germline nulls die at midgestation with disorganized somites and vascular defects, so conditional floxed alleles are required for adult neurogenesis, myogenesis, or intestinal work, and human haploinsufficiency causing neurodevelopmental disorder argues for heterozygous or hypomorphic designs. Since Dll4 and Jag1 activate the same receptors in overlapping fields, compound conditionals prevent misattributing residual signaling. Pair the flox with Sox2-Cre, Pax7-CreER, or Villin-CreER according to whether the endpoint is progenitor pool size, regeneration, or lineage allocation.
Global Dll1 deletion answers broad mechanism questions quickly. If timing or site matters, conditional alleles are a natural next step after the null is characterized.
What Dll1 Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Dll1 knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Dll1-KO | KO | KO | DEVELOPING | KO 264079 | Inquire |
| The exon3-4 of Dll1 gene was deleted to generate Dll1 knockout mouse. | |||||
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Dll1 Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Dll1 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Dll1 Knockout mouse models are available?
When Dll1 Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Dll1 knockout embryonic lethal in mice?
It depends on background and allele design. Some Dll1 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Dll1 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Dll1?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ITL
Send the Dll1 Knockout line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.