Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
DEVELOPING
Dll1 Conditional Knockout, Knockout mouse models
Browse 2 Dll1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Dll1 conditional knockout mouse, Dll1 knockout mouse. Contact us for availability and fast turnaround.
Why model Dll1
Dll1, ortholog of human DLL1, encodes Delta-like 1, a single-pass transmembrane Notch ligand with an N-terminal MNNL and DSL domain plus tandem EGF repeats that engages NOTCH1 and NOTCH2 in trans, and whose activity depends on MIB1-mediated ubiquitination and endocytic pulling force to expose the S2 cleavage site for ADAM10 and gamma-secretase. Oscillatory expression in presomitic mesoderm couples the segmentation clock to somite boundary formation, and the ligand also governs neural progenitor lateral inhibition, muscle progenitor maintenance, and intestinal secretory fate. Germline nulls die at midgestation with disorganized somites and vascular defects, so conditional floxed alleles are required for adult neurogenesis, myogenesis, or intestinal work, and human haploinsufficiency causing neurodevelopmental disorder argues for heterozygous or hypomorphic designs. Since Dll4 and Jag1 activate the same receptors in overlapping fields, compound conditionals prevent misattributing residual signaling. Pair the flox with Sox2-Cre, Pax7-CreER, or Villin-CreER according to whether the endpoint is progenitor pool size, regeneration, or lineage allocation.
What Dll1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Dll1 (DLL1) catalog mouse models in the Notch ligand family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Dll1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Dll1 allele types
Knockout, conditional, knockin, humanized, and related paths for Dll1 (human DLL1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Dll1 catalog models
2 Dll1 lines with QC documentation and technical support. Dll1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Dll1-Flox
CKOCKO
These mice carry loxP sites flanking exon3-4 of Dll1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Dll1 gene.
In DevelopmentCKO 264096 - Order
Dll1-KO
KOKO
The exon3-4 of Dll1 gene was deleted to generate Dll1 knockout mouse.
In DevelopmentKO 264079
Looking for a Dll1 mouse model?
We have 2 Dll1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Dll1 Mouse Model Types
A Dll1 knockout mouse has the Dll1 gene permanently inactivated, enabling loss of function studies. A Dll1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Dll1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Dll1 organized by modification type. Each URL is indexable and matches common search patterns.
Related Gene Targets
Breed this line with ITL
Send the Dll1 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.