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G6pc2 Knockout mouse models
G6pc2 is the mouse ortholog of human G6PC2 and encodes the islet-specific glucose-6-phosphatase catalytic subunit related protein, an endoplasmic reticulum membrane enzyme of beta cells that hydrolyzes glucose-6-phosphate and thereby opposes glucokinase, creating a futile cycle that raises the glucose threshold for insulin secretion. Human variants at G6PC2 are among the strongest fasting plasma glucose signals in GWAS, with loss-of-function alleles lowering fasting glucose without increasing diabetes risk, and mouse deletion reproduces this leftward shift in the glucose dose response for insulin release. The same protein is the IGRP antigen recognized by pathogenic CD8 T cells in NOD mice, giving the locus a second, immunological identity. Consequently a straight null suits secretion threshold studies, humanized knockins are the right tool for validating human coding variants and epitope-matched T cell work, and conditional alleles with Ins1-Cre confirm beta cell autonomy. Match allele to endpoint, whether hyperglycemic clamp, islet perifusion, or tetramer-based autoreactive T cell assays.
G6pc2 null animals are straightforward to genotype and phenotype when survival is acceptable. They remain a standard background for pharmacology, biomarker, and rescue studies.
What G6pc2 Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct G6pc2 knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| G6pc2-KO | KO | KO | DEVELOPING | KO 261335 | Inquire |
| The exon 3 of G6pc2 gene was deleted to generate G6pc2 knockout mouse. | |||||
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The G6pc2 Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a G6pc2 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What G6pc2 Knockout mouse models are available?
When G6pc2 Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is G6pc2 knockout embryonic lethal in mice?
It depends on background and allele design. Some G6pc2 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live G6pc2 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for G6pc2?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ITL
Send the G6pc2 Knockout line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.