Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
LIVE · DEVELOPING
G6pc2 Conditional Knockout, Knockout mouse models
Browse 2 G6pc2 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as G6pc2 conditional knockout mouse, G6pc2 knockout mouse. Request a quote within 24 hours.
Why model G6pc2
G6pc2 is the mouse ortholog of human G6PC2 and encodes the islet-specific glucose-6-phosphatase catalytic subunit related protein, an endoplasmic reticulum membrane enzyme of beta cells that hydrolyzes glucose-6-phosphate and thereby opposes glucokinase, creating a futile cycle that raises the glucose threshold for insulin secretion. Human variants at G6PC2 are among the strongest fasting plasma glucose signals in GWAS, with loss-of-function alleles lowering fasting glucose without increasing diabetes risk, and mouse deletion reproduces this leftward shift in the glucose dose response for insulin release. The same protein is the IGRP antigen recognized by pathogenic CD8 T cells in NOD mice, giving the locus a second, immunological identity. Consequently a straight null suits secretion threshold studies, humanized knockins are the right tool for validating human coding variants and epitope-matched T cell work, and conditional alleles with Ins1-Cre confirm beta cell autonomy. Match allele to endpoint, whether hyperglycemic clamp, islet perifusion, or tetramer-based autoreactive T cell assays.
What G6pc2 mouse models are available?
ingenious targeting laboratory offers 2 distinct G6pc2 (G6PC2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
G6pc2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
G6pc2 allele types
Knockout, conditional, knockin, humanized, and related paths for G6pc2 (human G6PC2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available G6pc2 catalog models
2 G6pc2 lines with QC documentation and technical support. G6pc2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
G6pc2-Flox
CKOCKO
These mice carry loxP sites flanking exon 3 of G6pc2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of G6pc2 gene.
LiveCKO 254121 - Order
G6pc2-KO
KOKO
The exon 3 of G6pc2 gene was deleted to generate G6pc2 knockout mouse.
In DevelopmentKO 261335
Looking for a G6pc2 mouse model?
We have 2 G6pc2 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About G6pc2 Mouse Model Types
A G6pc2 knockout mouse has the G6pc2 gene permanently inactivated, enabling loss of function studies. A G6pc2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of G6pc2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for G6pc2 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ITL
Send the G6pc2 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.