Gabra3 Knockout mouse models
Located on the X chromosome within a cluster with Gabrq and Gabre, Gabra3 encodes the α3 GABA-A receptor subunit, ortholog of human GABRA3, which assembles with β and γ2 subunits into receptors enriched in the thalamic reticular nucleus, monoaminergic brainstem nuclei, amygdala and neonatal cortex, where they generate slowly deactivating inhibitory currents that shape burst firing and oscillatory output. Expression is highest perinatally and declines as α1 rises, so developmental timing governs any phenotype. Diazepam-insensitive knockin analysis assigned α3 no essential role in classical sedation or anxiolysis but implicated it in antipsychotic-relevant sensorimotor gating and in spinal nociception, motivating α3-selective positive allosteric modulators as nonsedating analgesics. Human missense variants cause X-linked intellectual disability with epilepsy. Choose a conditional null crossed to a thalamic reticular or serotonergic driver for circuit questions, a benzodiazepine-insensitive knockin for subtype pharmacology, and remember that hemizygous males give the cleanest dosage comparison to patients.
Gabra3 null animals are straightforward to genotype and phenotype when survival is acceptable. They remain a standard background for pharmacology, biomarker, and rescue studies.
What Gabra3 Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Gabra3 knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Gabra3-KO | Knockout | KO/CKO mice | embryo cryopreservation | KO 200212 | Inquire |
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Gabra3 Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Gabra3 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Gabra3 Knockout mouse models are available?
When Gabra3 Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Gabra3 knockout embryonic lethal in mice?
It depends on background and allele design. Some Gabra3 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Gabra3 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Gabra3?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.