Gabrq Knockout mouse models
Gabrq, the mouse ortholog of human GABRQ, encodes the theta subunit of the GABA-A receptor, an atypical subunit that assembles with epsilon and alpha3 rather than the canonical alpha1/beta2/gamma2 arrangement, and it sits in the X-linked cluster alongside Gabra3 and Gabre. Theta-containing pentamers concentrate in monoaminergic and hypothalamic circuits, including locus coeruleus, dorsal raphe, and preoptic area, where they confer reduced benzodiazepine sensitivity, altered anesthetic and neurosteroid responses, and in some configurations agonist-independent spontaneous opening. Because the subunit tunes gating rather than forming a receptor by itself, conditional null alleles ask whether removing theta shifts tonic inhibition and arousal state, while epitope-matched humanization supports subunit-selective positive allosteric modulators whose pockets diverge between species. Epsilon subunits occupy overlapping pentamer positions, so plan compound Gabre genetics early, and pair the allele with monoamine-restricted drivers such as Dbh-Cre or Slc6a4-Cre when circuit-level endpoints are the goal.
Global Gabrq deletion answers broad mechanism questions quickly. If timing or site matters, conditional alleles are a natural next step after the null is characterized.
What Gabrq Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Gabrq knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Gabrq-KO | Knockout | KO/CKO mice | embryo cryopreservation | KO 190579 | Inquire |
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Gabrq Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Gabrq allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Gabrq Knockout mouse models are available?
When Gabrq Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Gabrq knockout embryonic lethal in mice?
It depends on background and allele design. Some Gabrq germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Gabrq animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Gabrq?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.