READY TO SHIP!
IN PRODUCTION
Grem2 Conditional Knockout mouse models
Grem2, the mouse ortholog of human GREM2, encodes the DAN-family antagonist PRDC, a secreted dimer that binds BMP2 and BMP4 with high affinity to block receptor assembly and lower SMAD1, SMAD5, and SMAD8 output in dental mesenchyme, bone remodeling compartments, atrial myocardium, and ovarian follicles. Human heterozygous variants cause autosomal dominant tooth agenesis, and locus variation associates with atrial fibrillation, consistent with BMP tone shaping both odontogenic placode signaling and atrial electrical remodeling. Nulls are viable, so germline deletion is usable, yet conditional alleles are preferable for distinguishing developmental tooth patterning from adult bone turnover and atrial conduction phenotypes. Knocking in patient missense alleles tests whether variants impair secretion, dimerization, or BMP capture, while humanization supports antagonist-directed biologics. Grem1 and noggin cover overlapping BMP-buffering roles in bone and dental mesenchyme, so compound conditional genetics protects against dismissing a real requirement after single-locus knockout.
A floxed Grem2 allele paired with Cre gives spatial control that whole body knockouts cannot offer. People use it to separate developmental roles from adult homeostasis, to model somatic mutations, and to match disease that begins in one organ.
What Grem2 Conditional Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Grem2 conditional knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Grem2-Flox | CKO | CKO | IN PRODUCTION | CKO 260106 | Inquire |
| These mice carry loxP sites flanking exon 2 of Grem2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Grem2 gene. | |||||
Why this approach
Conditional knockout focuses the experiment on your target tissue while the rest of the animal keeps a wild type allele. That pattern mirrors somatic mutation in patients and avoids systemic compensation that can erase subtle phenotypes. It is often preferred when a germline null is lethal, weak, or confounded by developmental rescue.
Pricing and quotes
The Grem2 Conditional Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Grem2 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Grem2 Conditional Knockout mouse models are available?
When Grem2 Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Grem2 knockout embryonic lethal in mice?
It depends on background and allele design. Some Grem2 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Grem2 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Grem2?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ingenious targeting laboratory
Send the Grem2 Conditional Knockout line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.