Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
EMBRYO · IN PRODUCTION
Grem2 Conditional Knockout, Knockout mouse models
Browse 2 Grem2 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Grem2 conditional knockout mouse, Grem2 knockout mouse. Request a quote within 24 hours.
Why model Grem2
Grem2, the mouse ortholog of human GREM2, encodes the DAN-family antagonist PRDC, a secreted dimer that binds BMP2 and BMP4 with high affinity to block receptor assembly and lower SMAD1, SMAD5, and SMAD8 output in dental mesenchyme, bone remodeling compartments, atrial myocardium, and ovarian follicles. Human heterozygous variants cause autosomal dominant tooth agenesis, and locus variation associates with atrial fibrillation, consistent with BMP tone shaping both odontogenic placode signaling and atrial electrical remodeling. Nulls are viable, so germline deletion is usable, yet conditional alleles are preferable for distinguishing developmental tooth patterning from adult bone turnover and atrial conduction phenotypes. Knocking in patient missense alleles tests whether variants impair secretion, dimerization, or BMP capture, while humanization supports antagonist-directed biologics. Grem1 and noggin cover overlapping BMP-buffering roles in bone and dental mesenchyme, so compound conditional genetics protects against dismissing a real requirement after single-locus knockout.
What Grem2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Grem2 (GREM2) catalog mouse models in the Antagonist/modulator family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Grem2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Grem2 allele types
Knockout, conditional, knockin, humanized, and related paths for Grem2 (human GREM2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Grem2 catalog models
2 Grem2 lines with QC documentation and technical support. Grem2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Grem2-Flox
CKOCKO
These mice carry loxP sites flanking exon 2 of Grem2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Grem2 gene.
In production — inquireCKO 260106 - Order
Grem2-KO
KOKO
Exon 2 of Grem2 gene was deleted to generate Grem2 knockout mice.
F0 Embryo CryopreservedKO 200845
Looking for a Grem2 mouse model?
We have 2 Grem2 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Grem2 Mouse Model Types
A Grem2 knockout mouse has the Grem2 gene permanently inactivated, enabling loss of function studies. A Grem2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Grem2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Grem2 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Grem2 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.