Grem2 Knockout mouse models
Grem2, the mouse ortholog of human GREM2, encodes the DAN-family antagonist PRDC, a secreted dimer that binds BMP2 and BMP4 with high affinity to block receptor assembly and lower SMAD1, SMAD5, and SMAD8 output in dental mesenchyme, bone remodeling compartments, atrial myocardium, and ovarian follicles. Human heterozygous variants cause autosomal dominant tooth agenesis, and locus variation associates with atrial fibrillation, consistent with BMP tone shaping both odontogenic placode signaling and atrial electrical remodeling. Nulls are viable, so germline deletion is usable, yet conditional alleles are preferable for distinguishing developmental tooth patterning from adult bone turnover and atrial conduction phenotypes. Knocking in patient missense alleles tests whether variants impair secretion, dimerization, or BMP capture, while humanization supports antagonist-directed biologics. Grem1 and noggin cover overlapping BMP-buffering roles in bone and dental mesenchyme, so compound conditional genetics protects against dismissing a real requirement after single-locus knockout.
Global Grem2 deletion answers broad mechanism questions quickly. If timing or site matters, conditional alleles are a natural next step after the null is characterized.
What Grem2 Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Grem2 knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Grem2-KO | Knockout | KO/CKO mice | embryo cryopreservation | KO 200845 | Inquire |
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Grem2 Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Grem2 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Grem2 Knockout mouse models are available?
When Grem2 Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Grem2 knockout embryonic lethal in mice?
It depends on background and allele design. Some Grem2 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Grem2 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Grem2?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.