What H11 Knockin mouse models are available?

When H11 Knockin lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.

Is H11 knockout embryonic lethal in mice?

It depends on background and allele design. Some H11 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.

Which Cre driver is best for experiments?

Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.

Do you ship live H11 animals?

When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.

How do I request a quote for H11?

Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.

●65 Models Available

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LIVE · SPERM · EMBRYO · DEVELOPING · IN PRODUCTION

H11 Knockin, Xenograft-Applicable mouse models

Browse 65 H11 mouse models including knockin, xenograft-applicable variants — in stock and ready to ship from ingenious targeting laboratory. Available as H11 knockin mouse, H11 xenograft-applicable mouse. Request a quote within 24 hours.

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Available H11 catalog models

65 H11 lines with QC documentation and technical support.

H11-CAG-RSR-EYFP
KI
Overexpression, Fluorescent Model
A CAG-ROX-STOP-ROX-EYFP-V5tag-polyA conditional expression cassette was knocked into the Igs2 locus (Hipp11 or H11; an intergenic region on chromosome 11 [cytoband A1 at ~3cM between the Eif4enif1 and Drg1 loci] reported to support high-level global gene expression in conjunction with the CAG (CAGGS) promoter and a higher rate of mitotic/interchromosomal recombination compared to Gt(ROSA)26Sor) . This strain of mice can be used to mate with mice expressing the Dre recombinase. After exposure to Dre recombinase, expression of ellow fluorescent protein and V5 tag is observed for cell tracking.
Sperm CryopreservedKI 18056
Order
H11-pAlb-NTCP-C9-IRES-EGFP
KI
Overexpression, Fluorescent Model, Disease Model
These mice harbor a 2xins-Alb-NTCP-C9 tag-IRES-EGFP-Wpre-pA-2xIns cassette in the lgs2 locus generated by homologous recombination.
Sperm CryopreservedKI 200054
Order
H11-CAG-LSL-hPSEN1-IRES-tdTomato
KI
Overexpression, Fluorescent Model, Target-Humanized
These mice harbor a CAG-LSL-PSEN1-IRES-tdTomato-WPRE-polyA cassette in mouse H11 locus via homologous recombination.
Embryo CryopreservedKI 190110
Order
H11-CAG-LSL-rtTA-IRES-tdtomato
KI
Overexpression, Fluorescent Model, Other Toolbox (non-Cre, non-Fluorescent)
These mice harbor a CAG-LSL-M2rtTA-FRT-IRES-tdtomato-FRT cassette in the lgs2 locus generated by homologous recombination.
Sperm CryopreservedKI 190064
Order
H11-pThy1-hPSEN1-IRES-tdTomato
KI
Overexpression, Fluorescent Model, Target-Humanized
A Thy1 promoter-PSEN1-IRES-tdTomato-WPRE-polyA cassette was knocked into the Igs2 locus (Hipp11 or H11; an intergenic region on chromosome 11 [cytoband A1 at ~3cM between the Eif4enif1 and Drg1 loci] reported to support high-level global gene expression in conjunction with the CAG (CAGGS) promoter and a higher rate of mitotic/interchromosomal recombination compared to Gt(ROSA)26Sor) .
Embryo CryopreservedKI 18049
Order
H11-CAG-LSL-mtagBFP2
KI
Overexpression, Fluorescent Model
A CAG-LSL-mTagBFP2-3xFLAG-WPRE-polyA cassette was inserted at the mouse H11 locus. When bred to a strain expressing Cre recombinase under control of various tissue specific promoters, Cre recombination deletes the LSL cassette and allows the expression of the mTagBFP2-3xFLAG protein.
Sperm CryopreservedKI 190006
Order
H11-CAG-LSL-hLILRB4-IRES-EGFP
KI
Overexpression, Fluorescent Model, Target-Humanized
CAG-loxP-STOP-loxP-hLILRB4-IRES-EGFP-WPRE-pA expression cassette was knocked into the the lgs2 (H11) locus.
Sperm CryopreservedKI 230387
Order
H11-GFAP-Jph4-GSlinker-Myc
KI
Overexpression
GFAP-Jph4-GSlinker-Myc-WPRE-polyA expression cassette was knocked into the H11 locus.
Sperm CryopreservedKI 225081
Order
H11-ED-L2-Cre-ED-L2-Cre
KI
Overexpression, Cre/Dre Toolbox
ED-L2-Cre-WPRE-pA-Frt-ED-L2-Cre-WPRE-pA-Frt expression cassette was knocked into the H11 locus .
Sperm CryopreservedKI 225093
Order
H11-PGK-Hygro-polyA
KI
Overexpression
The PGK-Hygromycin-polyA-PGK-Hygromycin-polyA-PGKHygromycin-polyA expression cassette was knocked into the H11 locus.
Sperm CryopreservedKI 232837
Order
H11-pAlb-hBAFF
KI
Overexpression, Target-Humanized
The pAlb-hBAFF-pA expression cassette was knocked into the H11 locus.
Sperm CryopreservedKI 232137
Order
H11-CAG-ddCre
KI
Overexpression, Other Toolbox (non-Cre, non-Fluorescent)
These H11-(CAG-ddCre-V5-polyA) mice are established by knocking CAG-LSL-ddCre-V5-polyA conditional expression cassette in mouse H11 loci.
Embryo CryopreservedKI 00086
Order
H11-CAG-LSL-hACHE
KI
Overexpression, Target-Humanized
These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven ACHE gene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. ACHE is expressed when bred to mice that express Cre recombinase.
Embryo CryopreservedKI 00067
Order
H11-CAG-EGFP
KI
Overexpression, Fluorescent Model
These mice harbor a CAG promoter-driven EGFP report gene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination.
LiveKI 00066
Order
H11-pAlb-hHAO1
KI
Overexpression, Target-Humanized
The pAlb-hHAO1 CDS-hHAO1 3'UTR-pA expression cassette was knocked into the H11 locus.
Embryo CryopreservedKI 231910
Order
H11-CAG-LSL-Mycn-IRES-EGFP
KI
Overexpression, Fluorescent Model, Disease Model
These mice harbor a CAG-LSL-HA tag-Mycn-IRES-EGFP cassette in the lgs2 locus generated by homologous recombination.
Embryo CryopreservedKI 190084
Order
H11-CAG-LSL-Irf1-IRES-EGFP
KI
Other
CAG-loxP-Neo-Long-STOP-loxP-Kozak-Irf1-IRES-EGFP-WPRE-pA expression cassette was knocked into the the Igs2 locus.
In DevelopmentKI 263948
Order
H11-Alb-SCARF2
KI
Other
Alb promoter-Kozak-SCARF2-pA expression cassette was knocked into the the Igs2 locus.
In DevelopmentKI 263947
Order
H11-pZp3-Cre
KI
Other
Zp3 promoter-Cre-pA expression cassette was knocked into the the Igs2 locus.
In DevelopmentKI 263921
Order
H11-pGdf9-Cre
KI
Cre/Dre Toolbox
Gdf9 promoter-Kozak-Cre-pA expression cassette was knocked into the the Igs2 locus.
In DevelopmentKI 263920
Order
H11-CAG-LSL-mYongHong ×4
KI
Other
CAG-LSL-Kozak-mYongHong-P2A-mYongHong-T2A-mYongHong-E2A-mYongHong-WPRE-pA expression cassette was knocked into the the Igs2 locus.
In DevelopmentKI 263909
Order
H11-pMUP-uPA
KI
Other
pMUP-uPA-hGH-pA expression cassette was knocked into the the Igs2 locus.
In DevelopmentKI 263628
Order
H11-pTyr-CreERT2
KI
Cre/Dre Toolbox
Tyr promoter-CreERT2-WPRE-pA expression cassette was knocked into the the Igs2 locus.
In DevelopmentKI 262955
Order
H11-pTRE3G-MVP-IRES-PABP-INT-CAG-LSL-Tet-On-3G
KI
Other Toolbox (non-Cre, non-Fluorescent)
insulator-insulator-pTRE3G-Kozak-MVP-IRES-PABP-INT-pA-insulator-insulator-CAG-LSL-Tet-On-3G-pA expression cassette was knocked into the the Igs2 locus.
In DevelopmentKI 261652
Order
H11-CAG-LSL-H2B-ZsGreen
KI
Overexpression, Fluorescent Model
CAG-LSL-Kozak-H2B-ZsGreen-WPRE-pA expression cassette was knocked into the the Igs2 locus.
LiveKI 260044
Order
H11-CAG-LSL-Myc*T58A-IRES-Luc
KI
Point Mutation, Overexpression, Fluorescent Model
CAG-LSL-Kozak-Myc*T58A-IRES-Luciferase-WPRE-pA expression cassette was knocked into the the Igs2 locus.
Sperm CryopreservedKI 253650
Order
H11-RIP-hCD80(BALB/c)
KI
Overexpression, Target-Humanized
RIP-Kozak-hCD80-WPRE-pA expression cassette was knocked into the the Igs2 locus.
Sperm CryopreservedKI 253103
Order
H11-CAG-LSL-Cox8a-Dendra2
KI
Overexpression
CAG-loxP-STOP-loxP-Kozak-Cox8a-Dendra2-WPRE-pA expression cassette was knocked into the the Igs2 locus.
LiveKI 252667
Order
H11-pCD2-TCRa(OT-II)
KI
Overexpression
CD2-TCRa(OT-II) expression cassette was knocked into the the Igs2 locus.
Sperm CryopreservedKI 252437
Order
H11-pCD2-TCRb(OT-II)
KI
Overexpression
CD2-TCRb(OT-II) expression cassette was knocked into the the Igs2 locus.
In production — inquireKI 252436
Order
H11-IL3-CSF2-KITLG(M-NSG)
KI
Overexpression, Immunodeficient, Target-Humanized
IL3-CSF2-KITLG expression cassette was knocked into the the Igs2 locus. Also known as H11-NSG-SGM3
LiveKI 252296
Order
H11-SIGLEC6
KI
Overexpression, Target-Humanized
SIGLEC6 expression cassette was knocked into the the Igs2 locus.
LiveKI 251862
Order
H11-CAG-RSR-tdTomato
KI
Overexpression, Fluorescent Model
These mice harbor a CAG-Rox-STOP-Rox-tdTomato conditional expression cassette in mouse H11 locus via homologous recombination.
LiveKI 18009
Order
H11-CAG-LSL-ZsGreen-CAG-RSR-tdTomato
KI
Overexpression, Fluorescent Model
A CAG-LSL-ZsGreen-wpre-pA-CAG-RSR-tdTomato-wpre-pA expression cassette was knocked into the H11 locus.
LiveKI 200319
Order
H11-CAG-LSL-Hba-a1-CAG-LSL-Hba-a2
KI
Overexpression
The CAG-LSL-Hba-a1-WPRE-pA-CAG-lox2272-STOP-lox2272-Hba-a2-WPRE-pA expression cassette was knocked into the H11 locus.
Sperm CryopreservedKI 242963
Order
H11-α-Cre-IRES-EGFP
KI
Overexpression, Cre/Dre Toolbox, Fluorescent Model
The α promoter-Cre-IRES-EGFP-WPRE-pA expression cassette was knocked into the H11 locus.
Sperm CryopreservedKI 231879
Order
H11-Vil1 promoter-rtTA-TetO-rox-Cre-pA-rox-cCre/R26-CAG-LSL-RSR-tdTomato-2A-DTR
KI
Overexpression, Cre/Dre Toolbox, Fluorescent Model, Other Toolbox (non-Cre, non-Fluorescent)
The Vil1 promoter-rtTA-pA-Ins-Ins-TetO-rox-Cre-pA-rox-cCre-WPRE-pA expression cassette was knocked into the H11 locus.
Sperm CryopreservedKI 232454
Order
H11-CAG-LSL-hHTTQ148-hHTT 3'UTR
KI
Overexpression, Target-Humanized
The CAG-loxP-STOP-loxP-hHTTQ148-hHTT 3'UTR-pA expression cassette was knocked into the H11 locus.
Sperm CryopreservedKI 234493
Order
H11-CAG-LSL-Myc
KI
Overexpression, Disease Model
The c-Myc gene (also known as Myc) is abnormally expressed in many tumors and plays a critical role in the regulation of cell proliferation, growth and metabolism, gene instability, stimulation of angiogenesis, malignant transformation, cell differentiation and apoptosis. These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Myc oncogene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. Myc is expressed when bred to mice that express Cre recombinase.
LiveKI 00039
Order
H11-U6-gRNA1(Tyr)-U6-gRNA2(Tyr)-U6-gRNA1(Tgm3)-U6-gRNA2(Tgm3)
KI
Overexpression
The U6-gRNA1(Tyr)-U6-gRNA2(Tyr)-U6-gRNA1(Tgm3)-U6-gRNA2(Tgm3) expression cassette was knocked into the H11 locus.
In DevelopmentKI 242755
Order
H11-loxp2217-U6-gRNA(lep)-loxp
KI
Overexpression
The loxp2217-U6-gRNA(lep)-loxp expression cassette was knocked into the H11 locus.
In DevelopmentKI 232217
Order
H11-CAG-LSL-H2B-EGFP-CAG-RSR-tdTomato
KI
Overexpression, Fluorescent Model
The CAG-LSL-H2B-EGFP-WPRE-pA-CAG-RSR-tdTomato-WPRE-pA expression cassette was knocked into the H11 locus.
Sperm CryopreservedKI 240880
Order
H11-pAlb-hALB-IRES-Luc
KI
Overexpression, Fluorescent Model, Target-Humanized
An ALB promoter-human ALB-IRES-Luciferase-polyA expression cassette was knocked into the H11 locus.
Embryo CryopreservedKI 200322
Order
H11-CAG-LSL-LSL-hMYCN-IRES-EGFP
KI
Overexpression, Fluorescent Model, Target-Humanized
A CAG-loxp-Neo-Stop-loxp-lox2272-Neo-Stop-lox2272-HA tag-NMYC-IRES-EFGP-WPRE-polyA expression cassette was knocked into via the lgs2 (H11) locus.
Sperm CryopreservedKI 210145
Order
H11-CAG-LSL-PLK1-IRES-Luc
KI
Overexpression, Fluorescent Model
CAG-Loxp-Stop-Loxp-PLK1-IRES-Luc-WPRE-polyA expression cassette was knocked into the the lgs2 (H11) locus.
Sperm CryopreservedKI 215103
Order
H11-CAG-lox-H2B-EBFP2-lox-tdTomato-lox-EYFP-lox-mCerulean
KI
Overexpression, Fluorescent Model
A CAG-lox-H2B-EBFP2-lox-tdTomato-lox-EYFP-lox-mCerulean expression cassette was knocked into the lgs2 (H11) locus.
Sperm CryopreservedKI 215007
Order
H11-pT3(b)-hIL15-Flag
KI
Overexpression, Other Toolbox (non-Cre, non-Fluorescent), Target-Humanized
pT3(b)-Kozak-hIL2 signal peptide-hIL15-Flag-polyA-pT3(b)-Kozak-hIL2 signal peptide-hIL15-Flag-polyA expression cassette was knocked into the the lgs2 (H11) locus.
Sperm CryopreservedKI 220128
Order
H11-pK18-hACE2
KI
Overexpression, Target-Humanized
K18-hACE2 expression cassette was knocked into the the lgs2 (H11) locus.
Sperm CryopreservedKI 225001
Order
H11-CAG-attB-STOP-attp-tdTomato
KI
Overexpression, Fluorescent Model
CAG-attB-STOP-attp-tdTomato-WPRE-pA expression cassette was knocked into the the lgs2 (H11) locus.
Sperm CryopreservedKI 230057
Order
H11-phTPO-Cre-ERT2(BALB/c)
KI
Overexpression, Cre/Dre Toolbox
The phTPO-Cre-Frt-ERT2-Frt-pA expression cassette was knocked into the H11 locus.
Sperm CryopreservedKI 234653
Order
H11-IL3-CSF2-KITLG/hIL15-TgV1(M-NSG)
XA
Target-Humanized, Immunodeficient
The hIL15-TgV1(NMG) (KI 220133) was crossed with H11-IL3-CSF2-KITLG(NMG)(KI 252296) to generate hIL15-TgV1(NMG)/H11-IL3-CSF2-KITLG(NMG) mice.
In DevelopmentXA 264018
Order
H11-IL3-CSF2-KITLG/Kit-V831M(M-NSG)
XA
Target-Humanized, Immunodeficient
The Kit-V831M(NMG) (KI 242813) was crossed with H11-IL3-CSF2-KITLG(NMG)(KI 252296) to generate Kit-V831M(NMG)/H11-IL3-CSF2-KITLG(NMG) mice.
In DevelopmentXA 264017
Order
H11-CAG-LSL-Myc*T58A-IRES-Luc/Trp53-Flox
XA
CKO, Point Mutation, Overexpression, Fluorescent Model
Based on Trp53-Flox (CKO 18005), the CAG-LSL-Kozak-Myc*T58A-IRES-Luciferase-WPRE-pA sequence was inserted into the Igs2 locus of mice, resulting in the generation of H11-CAG-LSL-Myc*T58A-IRES-Luciferase-WPRE-pA mice with dual gene modifications of Trp53-Flox.
Sperm CryopreservedXA 253651
Order
H11-pAlb-hBAFF/hAPRIL
XA
Overexpression, Target-Humanized
The H11-pAlb-hBAFF (KI 232137) was crossed with hAPRIL(HU 220521) to generate H11-pAlb-hBAFF/hAPRIL mice.
LiveXA 252033
Order
H11-CAG-RSR-tdTomato/Hbb-bs-Linker-HA-2A-DreERT2
XA
Other
The Hbb-bs-Linker-HA-2A-DreERT2 (KI 261391) was crossed with H11-CAG-RSR-tdTomato(KI 18009) to generate Hbb-bs-Linker-HA-2A-DreERT2/H11-CAG-RSR-tdTomato mice.
In DevelopmentXA 263935
Order
H11-CAG-LSL-ZsGreen-CAG-RSR-tdTomato/Cdkn2a-2A-DreERT2(p16-2A-DreERT2)
XA
Overexpression, Fluorescent Model
The H11-CAG-LSL-ZsGreen-CAG-RSR-tdTomato (KI 200319) was crossed with Cdkn2a-2A-DreERT2(p16-2A-DreERT2)(KI 225086) to generate H11-CAG-LSL-ZsGreen-CAG-RSR-tdTomato/Cdkn2a-2A-DreERT2(p16-2A-DreERT2) mice.
In DevelopmentXA 253373
Order
H11-pSFTPC-hTSLP/hCRLF2(BALB/c)
XA
Overexpression, Target-Humanized
The H11-pSFTPC-hTSLP(BALB/c) (KI 241307) was crossed with hCRLF2(BALB/c)(HU 241304) to generate H11-pSFTPC-hTSLP(BALB/c)/hCRLF2(BALB/c) mice.
In DevelopmentXA 251534
Order
H11-pSFTPC-hTSLP/hCRLF2/hIL7R(BALB/c)
XA
Overexpression, Target-Humanized
The H11-pSFTPC-hTSLP/hCRLF2(BALB/c) (XA 251534) was crossed with hIL7R(BALB/c)(HU 241305) to generate H11-pSFTPC-hTSLP/hCRLF2(BALB/c)/hIL7R(BALB/c) mice.
In DevelopmentXA 251535
Order
H11-CAG-LSL-H2B-ZsGreen/Stra8-2A-tdTomato-2A-Cre
XA
Other
The H11-CAG-LSL-H2B-ZsGreen (KI 260044) was crossed with Stra8-2A-tdTomato-2A-Cre(KI 225030) to generate H11-CAG-LSL-H2B-ZsGreen/Stra8-2A-tdTomato-2A-Cre mice.
In DevelopmentXA 263714
Order
H11-IL3-CSF2-KITLG/hIL15-Tg(M-NSG)
XA
Target-Humanized, Immunodeficient
The hIL15-Tg(NMG) (KI 210141) was crossed with H11-IL3-CSF2-KITLG(NMG)(KI 252296) to generate hIL15-Tg(NMG)/H11-IL3-CSF2-KITLG(NMG) mice.
In DevelopmentXA 264019
Order
H11-pSFTPC-hTSLP/hIL7R/hTSLP(BALB/c)
XA
Overexpression, Target-Humanized
The H11-pSFTPC-hTSLP/hTSLP(BALB/c) (XA 251525) was crossed with hIL7R(BALB/c)(HU 241305) to generate H11-pSFTPC-hTSLP/hTSLP(BALB/c)/hIL7R(BALB/c) mice.
Not DevelopedXA 251526
Order
H11-CAG-LSL-H2B-ZsGreen/Cx3cr1-Cre
XA
Cre/Dre Toolbox, Fluorescent Model
The H11-CAG-LSL-H2B-ZsGreen (KI 260044) was crossed with Cx3cr1-Cre(KI 200079) to generate H11-CAG-LSL-H2B-ZsGreen/Cx3cr1-Cre mice.
In DevelopmentXA 262490
Order
H11-pAlb-hBAFF/Itgam-IRES-hCD89/hIGHA1
XA
Target-Humanized
The H11-pAlb-hBAFF (KI 232137) was crossed with Itgam-IRES-hCD89/hIGHA1(HU 210412) to generate H11-pAlb-hBAFF/Itgam-IRES-hCD89/hIGHA1 mice.
In DevelopmentXA 262029
Order
H11-CAG-Arl13b-Linker-APEX2
XA
Overexpression
The H11-CAG-LSL-Arl13b-Linker-APEX2 (KI 241214) was crossed with Dppa3-IRES-Cre(KI 00040) to generate H11-CAG-Arl13b-Linker-APEX2 mice.
LiveXA 252433
Order
H11-pSFTPC-hTSLP/hTSLP(BALB/c)
XA
Overexpression, Target-Humanized
The H11-pSFTPC-hTSLP(BALB/c) (KI 241307) was crossed with hTSLP(BALB/c)(HU 241306) to generate H11-pSFTPC-hTSLP(BALB/c)/hTSLP(BALB/c) mice.
Not DevelopedXA 251525
Order

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About H11 Mouse Model Types

H11 knockin models carry a precisely inserted sequence at the H11 locus, useful for reporter, tag, or humanization studies.

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Modifications available

Jump to catalog backed pages for H11 organized by modification type. Each URL is indexable and matches common search patterns.

H11 Knockin H11 Xenograft-Applicable H11 cDNA Knockin H11 Conditional Knockout H11 Epitope Tag Knockin H11 Humanized H11 Knockout H11 Overexpression / Safe Harbor H11 Reporter

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