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H11 Knockin mouse models
Knockin designs at H11 support head to head comparisons between wild type and modified alleles because regulatory DNA stays in place.
What H11 Knockin mouse models are available?
ingenious targeting laboratory offers 50 distinct H11 knockin catalog mouse models. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| H11-CAG-RSR-EYFP | KI | Overexpression, Fluorescent Model | SPERM | KI 18056 | Inquire |
| A CAG-ROX-STOP-ROX-EYFP-V5tag-polyA conditional expression cassette was knocked into the Igs2 locus (Hipp11 or H11; an intergenic region on chromosome 11 [cytoband A1 at ~3cM between the Eif4enif1 and Drg1 loci] reported to support high-level global gene expression in conjunction with the CAG (CAGGS) promoter and a higher rate of mitotic/interchromosomal recombination compared to Gt(ROSA)26Sor) . This strain of mice can be used to mate with mice expressing the Dre recombinase. After exposure to Dre recombinase, expression of ellow fluorescent protein and V5 tag is observed for cell tracking. | |||||
| H11-pAlb-NTCP-C9-IRES-EGFP | KI | Overexpression, Fluorescent Model, Disease Model | SPERM | KI 200054 | Inquire |
| These mice harbor a 2xins-Alb-NTCP-C9 tag-IRES-EGFP-Wpre-pA-2xIns cassette in the lgs2 locus generated by homologous recombination. | |||||
| H11-CAG-LSL-hPSEN1-IRES-tdTomato | KI | Overexpression, Fluorescent Model, Target-Humanized | EMBRYO | KI 190110 | Inquire |
| These mice harbor a CAG-LSL-PSEN1-IRES-tdTomato-WPRE-polyA cassette in mouse H11 locus via homologous recombination. | |||||
| H11-CAG-LSL-rtTA-IRES-tdtomato | KI | Overexpression, Fluorescent Model, Other Toolbox (non-Cre, non-Fluorescent) | SPERM | KI 190064 | Inquire |
| These mice harbor a CAG-LSL-M2rtTA-FRT-IRES-tdtomato-FRT cassette in the lgs2 locus generated by homologous recombination. | |||||
| H11-pThy1-hPSEN1-IRES-tdTomato | KI | Overexpression, Fluorescent Model, Target-Humanized | EMBRYO | KI 18049 | Inquire |
| A Thy1 promoter-PSEN1-IRES-tdTomato-WPRE-polyA cassette was knocked into the Igs2 locus (Hipp11 or H11; an intergenic region on chromosome 11 [cytoband A1 at ~3cM between the Eif4enif1 and Drg1 loci] reported to support high-level global gene expression in conjunction with the CAG (CAGGS) promoter and a higher rate of mitotic/interchromosomal recombination compared to Gt(ROSA)26Sor) . | |||||
| H11-CAG-LSL-mtagBFP2 | KI | Overexpression, Fluorescent Model | SPERM | KI 190006 | Inquire |
| A CAG-LSL-mTagBFP2-3xFLAG-WPRE-polyA cassette was inserted at the mouse H11 locus. When bred to a strain expressing Cre recombinase under control of various tissue specific promoters, Cre recombination deletes the LSL cassette and allows the expression of the mTagBFP2-3xFLAG protein. | |||||
| H11-CAG-LSL-hLILRB4-IRES-EGFP | KI | Overexpression, Fluorescent Model, Target-Humanized | SPERM | KI 230387 | Inquire |
| CAG-loxP-STOP-loxP-hLILRB4-IRES-EGFP-WPRE-pA expression cassette was knocked into the the lgs2 (H11) locus. | |||||
| H11-GFAP-Jph4-GSlinker-Myc | KI | Overexpression | SPERM | KI 225081 | Inquire |
| GFAP-Jph4-GSlinker-Myc-WPRE-polyA expression cassette was knocked into the H11 locus. | |||||
| H11-ED-L2-Cre-ED-L2-Cre | KI | Overexpression, Cre/Dre Toolbox | SPERM | KI 225093 | Inquire |
| ED-L2-Cre-WPRE-pA-Frt-ED-L2-Cre-WPRE-pA-Frt expression cassette was knocked into the H11 locus . | |||||
| H11-PGK-Hygro-polyA | KI | Overexpression | SPERM | KI 232837 | Inquire |
| The PGK-Hygromycin-polyA-PGK-Hygromycin-polyA-PGKHygromycin-polyA expression cassette was knocked into the H11 locus. | |||||
| H11-pAlb-hBAFF | KI | Overexpression, Target-Humanized | SPERM | KI 232137 | Inquire |
| The pAlb-hBAFF-pA expression cassette was knocked into the H11 locus. | |||||
| H11-CAG-ddCre | KI | Overexpression, Other Toolbox (non-Cre, non-Fluorescent) | EMBRYO | KI 00086 | Inquire |
| These H11-(CAG-ddCre-V5-polyA) mice are established by knocking CAG-LSL-ddCre-V5-polyA conditional expression cassette in mouse H11 loci. | |||||
| H11-CAG-LSL-hACHE | KI | Overexpression, Target-Humanized | EMBRYO | KI 00067 | Inquire |
| These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven ACHE gene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. ACHE is expressed when bred to mice that express Cre recombinase. | |||||
| H11-CAG-EGFP | KI | Overexpression, Fluorescent Model | LIVE | KI 00066 | Inquire |
| These mice harbor a CAG promoter-driven EGFP report gene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. | |||||
| H11-pAlb-hHAO1 | KI | Overexpression, Target-Humanized | EMBRYO | KI 231910 | Inquire |
| The pAlb-hHAO1 CDS-hHAO1 3'UTR-pA expression cassette was knocked into the H11 locus. | |||||
| H11-CAG-LSL-Mycn-IRES-EGFP | KI | Overexpression, Fluorescent Model, Disease Model | EMBRYO | KI 190084 | Inquire |
| These mice harbor a CAG-LSL-HA tag-Mycn-IRES-EGFP cassette in the lgs2 locus generated by homologous recombination. | |||||
| H11-CAG-LSL-Irf1-IRES-EGFP | KI | Other | DEVELOPING | KI 263948 | Inquire |
| CAG-loxP-Neo-Long-STOP-loxP-Kozak-Irf1-IRES-EGFP-WPRE-pA expression cassette was knocked into the the Igs2 locus. | |||||
| H11-Alb-SCARF2 | KI | Other | DEVELOPING | KI 263947 | Inquire |
| Alb promoter-Kozak-SCARF2-pA expression cassette was knocked into the the Igs2 locus. | |||||
| H11-pZp3-Cre | KI | Other | DEVELOPING | KI 263921 | Inquire |
| Zp3 promoter-Cre-pA expression cassette was knocked into the the Igs2 locus. | |||||
| H11-pGdf9-Cre | KI | Cre/Dre Toolbox | DEVELOPING | KI 263920 | Inquire |
| Gdf9 promoter-Kozak-Cre-pA expression cassette was knocked into the the Igs2 locus. | |||||
| H11-CAG-LSL-mYongHong ×4 | KI | Other | DEVELOPING | KI 263909 | Inquire |
| CAG-LSL-Kozak-mYongHong-P2A-mYongHong-T2A-mYongHong-E2A-mYongHong-WPRE-pA expression cassette was knocked into the the Igs2 locus. | |||||
| H11-pMUP-uPA | KI | Other | DEVELOPING | KI 263628 | Inquire |
| pMUP-uPA-hGH-pA expression cassette was knocked into the the Igs2 locus. | |||||
| H11-pTyr-CreERT2 | KI | Cre/Dre Toolbox | DEVELOPING | KI 262955 | Inquire |
| Tyr promoter-CreERT2-WPRE-pA expression cassette was knocked into the the Igs2 locus. | |||||
| H11-pTRE3G-MVP-IRES-PABP-INT-CAG-LSL-Tet-On-3G | KI | Other Toolbox (non-Cre, non-Fluorescent) | DEVELOPING | KI 261652 | Inquire |
| insulator-insulator-pTRE3G-Kozak-MVP-IRES-PABP-INT-pA-insulator-insulator-CAG-LSL-Tet-On-3G-pA expression cassette was knocked into the the Igs2 locus. | |||||
| H11-CAG-LSL-H2B-ZsGreen | KI | Overexpression, Fluorescent Model | LIVE | KI 260044 | Inquire |
| CAG-LSL-Kozak-H2B-ZsGreen-WPRE-pA expression cassette was knocked into the the Igs2 locus. | |||||
| H11-CAG-LSL-Myc*T58A-IRES-Luc | KI | Point Mutation, Overexpression, Fluorescent Model | SPERM | KI 253650 | Inquire |
| CAG-LSL-Kozak-Myc*T58A-IRES-Luciferase-WPRE-pA expression cassette was knocked into the the Igs2 locus. | |||||
| H11-RIP-hCD80(BALB/c) | KI | Overexpression, Target-Humanized | SPERM | KI 253103 | Inquire |
| RIP-Kozak-hCD80-WPRE-pA expression cassette was knocked into the the Igs2 locus. | |||||
| H11-CAG-LSL-Cox8a-Dendra2 | KI | Overexpression | LIVE | KI 252667 | Inquire |
| CAG-loxP-STOP-loxP-Kozak-Cox8a-Dendra2-WPRE-pA expression cassette was knocked into the the Igs2 locus. | |||||
| H11-pCD2-TCRa(OT-II) | KI | Overexpression | SPERM | KI 252437 | Inquire |
| CD2-TCRa(OT-II) expression cassette was knocked into the the Igs2 locus. | |||||
| H11-pCD2-TCRb(OT-II) | KI | Overexpression | IN PRODUCTION | KI 252436 | Inquire |
| CD2-TCRb(OT-II) expression cassette was knocked into the the Igs2 locus. | |||||
| H11-IL3-CSF2-KITLG(M-NSG) | KI | Overexpression, Immunodeficient, Target-Humanized | LIVE | KI 252296 | Inquire |
| IL3-CSF2-KITLG expression cassette was knocked into the the Igs2 locus. Also known as H11-NSG-SGM3 | |||||
| H11-SIGLEC6 | KI | Overexpression, Target-Humanized | LIVE | KI 251862 | Inquire |
| SIGLEC6 expression cassette was knocked into the the Igs2 locus. | |||||
| H11-CAG-RSR-tdTomato | KI | Overexpression, Fluorescent Model | LIVE | KI 18009 | Inquire |
| These mice harbor a CAG-Rox-STOP-Rox-tdTomato conditional expression cassette in mouse H11 locus via homologous recombination. | |||||
| H11-CAG-LSL-ZsGreen-CAG-RSR-tdTomato | KI | Overexpression, Fluorescent Model | LIVE | KI 200319 | Inquire |
| A CAG-LSL-ZsGreen-wpre-pA-CAG-RSR-tdTomato-wpre-pA expression cassette was knocked into the H11 locus. | |||||
| H11-CAG-LSL-Hba-a1-CAG-LSL-Hba-a2 | KI | Overexpression | SPERM | KI 242963 | Inquire |
| The CAG-LSL-Hba-a1-WPRE-pA-CAG-lox2272-STOP-lox2272-Hba-a2-WPRE-pA expression cassette was knocked into the H11 locus. | |||||
| H11-α-Cre-IRES-EGFP | KI | Overexpression, Cre/Dre Toolbox, Fluorescent Model | SPERM | KI 231879 | Inquire |
| The α promoter-Cre-IRES-EGFP-WPRE-pA expression cassette was knocked into the H11 locus. | |||||
| H11-Vil1 promoter-rtTA-TetO-rox-Cre-pA-rox-cCre/R26-CAG-LSL-RSR-tdTomato-2A-DTR | KI | Overexpression, Cre/Dre Toolbox, Fluorescent Model, Other Toolbox (non-Cre, non-Fluorescent) | SPERM | KI 232454 | Inquire |
| The Vil1 promoter-rtTA-pA-Ins-Ins-TetO-rox-Cre-pA-rox-cCre-WPRE-pA expression cassette was knocked into the H11 locus. | |||||
| H11-CAG-LSL-hHTTQ148-hHTT 3'UTR | KI | Overexpression, Target-Humanized | SPERM | KI 234493 | Inquire |
| The CAG-loxP-STOP-loxP-hHTTQ148-hHTT 3'UTR-pA expression cassette was knocked into the H11 locus. | |||||
| H11-CAG-LSL-Myc | KI | Overexpression, Disease Model | LIVE | KI 00039 | Inquire |
| The c-Myc gene (also known as Myc) is abnormally expressed in many tumors and plays a critical role in the regulation of cell proliferation, growth and metabolism, gene instability, stimulation of angiogenesis, malignant transformation, cell differentiation and apoptosis. These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Myc oncogene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. Myc is expressed when bred to mice that express Cre recombinase. | |||||
| H11-U6-gRNA1(Tyr)-U6-gRNA2(Tyr)-U6-gRNA1(Tgm3)-U6-gRNA2(Tgm3) | KI | Overexpression | DEVELOPING | KI 242755 | Inquire |
| The U6-gRNA1(Tyr)-U6-gRNA2(Tyr)-U6-gRNA1(Tgm3)-U6-gRNA2(Tgm3) expression cassette was knocked into the H11 locus. | |||||
| H11-loxp2217-U6-gRNA(lep)-loxp | KI | Overexpression | DEVELOPING | KI 232217 | Inquire |
| The loxp2217-U6-gRNA(lep)-loxp expression cassette was knocked into the H11 locus. | |||||
| H11-CAG-LSL-H2B-EGFP-CAG-RSR-tdTomato | KI | Overexpression, Fluorescent Model | SPERM | KI 240880 | Inquire |
| The CAG-LSL-H2B-EGFP-WPRE-pA-CAG-RSR-tdTomato-WPRE-pA expression cassette was knocked into the H11 locus. | |||||
| H11-pAlb-hALB-IRES-Luc | KI | Overexpression, Fluorescent Model, Target-Humanized | EMBRYO | KI 200322 | Inquire |
| An ALB promoter-human ALB-IRES-Luciferase-polyA expression cassette was knocked into the H11 locus. | |||||
| H11-CAG-LSL-LSL-hMYCN-IRES-EGFP | KI | Overexpression, Fluorescent Model, Target-Humanized | SPERM | KI 210145 | Inquire |
| A CAG-loxp-Neo-Stop-loxp-lox2272-Neo-Stop-lox2272-HA tag-NMYC-IRES-EFGP-WPRE-polyA expression cassette was knocked into via the lgs2 (H11) locus. | |||||
| H11-CAG-LSL-PLK1-IRES-Luc | KI | Overexpression, Fluorescent Model | SPERM | KI 215103 | Inquire |
| CAG-Loxp-Stop-Loxp-PLK1-IRES-Luc-WPRE-polyA expression cassette was knocked into the the lgs2 (H11) locus. | |||||
| H11-CAG-lox-H2B-EBFP2-lox-tdTomato-lox-EYFP-lox-mCerulean | KI | Overexpression, Fluorescent Model | SPERM | KI 215007 | Inquire |
| A CAG-lox-H2B-EBFP2-lox-tdTomato-lox-EYFP-lox-mCerulean expression cassette was knocked into the lgs2 (H11) locus. | |||||
| H11-pT3(b)-hIL15-Flag | KI | Overexpression, Other Toolbox (non-Cre, non-Fluorescent), Target-Humanized | SPERM | KI 220128 | Inquire |
| pT3(b)-Kozak-hIL2 signal peptide-hIL15-Flag-polyA-pT3(b)-Kozak-hIL2 signal peptide-hIL15-Flag-polyA expression cassette was knocked into the the lgs2 (H11) locus. | |||||
| H11-pK18-hACE2 | KI | Overexpression, Target-Humanized | SPERM | KI 225001 | Inquire |
| K18-hACE2 expression cassette was knocked into the the lgs2 (H11) locus. | |||||
| H11-CAG-attB-STOP-attp-tdTomato | KI | Overexpression, Fluorescent Model | SPERM | KI 230057 | Inquire |
| CAG-attB-STOP-attp-tdTomato-WPRE-pA expression cassette was knocked into the the lgs2 (H11) locus. | |||||
| H11-phTPO-Cre-ERT2(BALB/c) | KI | Overexpression, Cre/Dre Toolbox | SPERM | KI 234653 | Inquire |
| The phTPO-Cre-Frt-ERT2-Frt-pA expression cassette was knocked into the H11 locus. | |||||
Why this approach
Knockin and humanized formats keep regulatory context at the endogenous locus. For your target tissue focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.
Pricing and quotes
The H11 Knockin lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a H11 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What H11 Knockin mouse models are available?
When H11 Knockin lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is H11 knockout embryonic lethal in mice?
It depends on background and allele design. Some H11 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live H11 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for H11?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Related models and routes
Breed this line with ingenious targeting laboratory
Send the H11 Knockin line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.