What HLA Humanized mouse models are available?

When HLA Humanized lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.

Is HLA knockout embryonic lethal in mice?

It depends on background and allele design. Some HLA germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.

Which Cre driver is best for experiments?

Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.

Do you ship live HLA animals?

When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.

How do I request a quote for HLA?

Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.

●38 Models Available

READY TO SHIP!

LIVE · SPERM · EMBRYO · DEVELOPING · IN PRODUCTION

HLA Humanized, Transgenic, Xenograft-Applicable mouse models

Browse 38 HLA mouse models including humanized, transgenic, xenograft-applicable variants — in stock and ready to ship from ingenious targeting laboratory. Available as HLA humanized mouse, HLA transgenic mouse, HLA xenograft-applicable mouse. Request a quote within 24 hours.

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Available HLA catalog models

38 HLA lines with QC documentation and technical support. HLA humanized models carry the human gene sequence for translational research.

HLA-DR4 (HLA-DRA*0101/HLA-DRB1*0401,Balb/c)
HU
Target-Humanized
This mouse model was derived from the existing HLA-DRA*0101 (BALB/c) (HU 263059) strain. Further humanization modification of the H2-Ab1 gene was carried out through homologous recombination technology.
In DevelopmentHU 263065
Order
HLA-DR1 (HLA-DRA*0101/HLA-DRB1*0101,Balb/c)
HU
Target-Humanized
This mouse model was derived from the existing HLA-DRA*0101 (BALB/c) (HU 263059) strain. Through homologous recombination technology, the H2-Ab1 gene was further modified for humanization.
In DevelopmentHU 263064
Order
HLA-E1.3/B2M(2)
HU
Target-Humanized
The endogenous mouse B2m gene was replaced by human B2M gene.
In production — inquireHU 261706
Order
HLA-A11.1/B2M(2)
HU
Target-Humanized
The endogenous mouse B2m gene was replaced by hB2M-linker-HLA-A*1101/H2-D1 gene.
LiveHU 241354
Order
HLA-A2.1/B2M
HU
Target-Humanized
The endogenous mouse B2m gene was replaced by hB2M-linker-HLA-A*0201/H2-D1 gene.
LiveHU 241353
Order
HLA-A24.2/B2M(2)
HU
Target-Humanized
The endogenous mouse B2m gene was replaced by hB2M-linker-HLA-A*2402/H2-D1 gene.
LiveHU 241352
Order
HLA-A1.1/B2M
HU
Target-Humanized
The endogenous mouse B2m gene was replaced by hB2M-linker-HLA-A*0101/H2-D1 gene.
LiveHU 241351
Order
HLA-A3.1/B2M
HU
Target-Humanized
The endogenous mouse B2m gene was replaced by hB2M-linker-HLA-A*0301/H2-D1.
LiveHU 250773
Order
HLA-A2.22/B2M
HU
Target-Humanized
The endogenous mice H2-D1 gene was replaced by human B2M/HLA-A2 gene
Sperm CryopreservedHU 210010
Order
HLA-A2.22
HU
Target-Humanized
The endogenous mice H2-D1 gene was replaced by human HLA-A2 gene.
Embryo CryopreservedHU 204988
Order
HLA-B27.5/B2M
HU
Target-Humanized
The endogenous mouse B2m gene was replaced by human B2M gene.
In production — inquireHU 261003
Order
HLA-B27.5/B2M(BALB/c)
HU
Target-Humanized
The endogenous mouse B2m gene was replaced by human B2M gene.
In production — inquireHU 260633
Order
HLA-A2.1/B2M(BALB/c)
HU
Target-Humanized
The endogenous mouse B2m gene was replaced by human B2M gene.
In production — inquireHU 260895
Order
HLA-A11.1/B2M(BALB/c)
HU
Target-Humanized
The endogenous mouse B2m gene was replaced by human B2M gene.
In production — inquireHU 260893
Order
HLA-A24.2/B2M(BALB/c)
HU
Target-Humanized
The endogenous mouse B2m gene was replaced by human B2M gene.
In production — inquireHU 260892
Order
HLA-A11.1/B2M(V1)
HU
Target-Humanized
The endogenous mouse H2-K1 gene was replaced by human HLA-A gene.
LiveHU 254021
Order
HLA-A24.2/B2M(V1)
HU
Target-Humanized
The endogenous mouse H2-D1 gene was replaced by human HLA-A gene.
In production — inquireHU 254020
Order
HLA-A2.1/B2M(V1)
HU
Target-Humanized
The endogenous mouse B2m gene was replaced by human B2M gene.
LiveHU 253999
Order
HLA-B39.1/B2M
HU
Target-Humanized
The endogenous mouse B2m gene was replaced by human HLA-B gene.
LiveHU 252702
Order
HLA-B7.2/B2M
HU
Target-Humanized
The endogenous mouse B2m gene was replaced by human HLA-B gene.
LiveHU 252701
Order
HLA-B58.1/B2M
HU
Target-Humanized
The endogenous mouse B2m gene was replaced by human HLA-B gene.
In production — inquireHU 252700
Order
HLA-B40.1/B2M
HU
Target-Humanized
The endogenous mouse B2m gene was replaced by human HLA-B gene.
LiveHU 252699
Order
HLA-A24.2/B2M(M-NSG)
HU
Target-Humanized, Immunodeficient
The endogenous mouse B2m gene was replaced by hB2M-linker-HLA-A*2402/H2-D1 gene.
In DevelopmentHU 252347
Order
HLA-A11.1/B2M(M-NSG)
HU
Target-Humanized, Immunodeficient
The endogenous mouse B2m gene was replaced by hB2M-linker-HLA-A*1101/H2-D1 gene.
LiveHU 252346
Order
HLA-A3.1/B2M(M-NSG)
HU
Target-Humanized, Immunodeficient
The endogenous mouse B2m gene was replaced by hB2M-linker-HLA-A*0301/H2-D1 gene.
LiveHU 252345
Order
HLA-DR1 (HLA-DRA*0101/HLA-DRB1*0101)
HU
Target-Humanized
The endogenous mouse H2-Aa gene was replaced by human HLA-DRA gene.The endogenous mouse H2-Ab1 gene was replaced by human HLA-DRB1*0101 gene.
In DevelopmentHU 241520
Order
HLA-DR4 (HLA-DRA*0101/HLA-DRB1*0401)
HU
Target-Humanized
The endogenous mouse H2-Aa gene was replaced by human HLA-DRA*0101 gene.The endogenous mouse H2-Ab1 gene was replaced by human HLA-DRB1*0401 gene.
In DevelopmentHU 241519
Order
HLA-DQ8
HU
Target-Humanized
The endogenous mouse H2-Aa gene was replaced by human HLA-DQA1*0301 gene. The endogenous mouse H2-Ab1 gene was replaced by human HLA-DQB1*0302 gene.
LiveHU 240843
Order
HLA-DPA1/HLA-DPB1
HU
Target-Humanized
The endogenous mouse H2-Aa gene was replaced by human HLA-DPA1*02:02 gene. The endogenous mouse H2-Ab1 gene was replaced by human HLA-DPB1*03:01 gene.
LiveHU 234679
Order
HLA-A2.1/B2M(M-NSG)(2)
HU
Target-Humanized, Immunodeficient
The endogenous mouse B2m gene was replaced by hB2M/HLA-A2.1/H2-D1 gene.
LiveHU 241683
Order
HLA-G/B2M
HU
Target-Humanized
The endogenous mouse B2m gene was replaced by human B2M/HLA-G gene.
Sperm CryopreservedHU 241967
Order
HLA-DQA2-Tg
TG
Target-Humanized, Random Transgenic
These transgenic strains harbor HLA-DQA2 expression cassettes.
Sperm CryopreservedTG 232501
Order
HLA-A11.1/B2M(2)/hPD-1/hPD-L1
XA
Target-Humanized
The HLA-A11.1/B2M(2) (HU 241354) was crossed with hPD-1/hPD-L1(HU 00100) to generate HLA-A11.1/B2M(2)/hPD-1/hPD-L1 mice.
In DevelopmentXA 261693
Order
HLA-A24.2/B2M(2)/hCD3EDG
XA
Target-Humanized
The HLA-A24.2/B2M(2) (HU 241352) was crossed with hCD3EDG(HU 220120) to generate HLA-A24.2/B2M(2)/hCD3EDG mice.
In DevelopmentXA 261692
Order
HLA-A24.2/B2M(2)/hPD-1/hPD-L1
XA
Target-Humanized
The HLA-A24.2/B2M(2) (HU 241352) was crossed with hPD-1/hPD-L1(HU 00100) to generate HLA-A24.2/B2M(2)/hPD-1/hPD-L1 mice.
In DevelopmentXA 261694
Order
HLA-A2.1/B2M/hCD3EDG
XA
Target-Humanized
The HLA-A2.1/B2M (HU 241353) was crossed with hCD3EDG(HU 220120) to generate HLA-A2.1/B2M/hCD3EDG mice.
In DevelopmentXA 261690
Order
HLA-A2.1/B2M/hIDO1/hPD-1/hPD-L1
XA
Target-Humanized
The hIDO1/HLA-A2.1/B2M (XA 252091) was crossed with hPD-1/hPD-L1(HU 00100) to generate hIDO1/HLA-A2.1/B2M/hPD-1/hPD-L1 mice.
LiveXA 260456
Order
HLA-A11.1/B2M(2)/hCD3EDG
XA
Target-Humanized
The HLA-A11.1/B2M(2) (HU 241354) was crossed with hCD3EDG(HU 220120) to generate HLA-A11.1/B2M(2)/hCD3EDG mice.
In DevelopmentXA 261691
Order

Looking for a HLA mouse model?

We have 38 HLA models in stock — including Humanized, Transgenic, Xenograft-Applicable types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.

Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.

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Models Available

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QC Documentation

About HLA Mouse Model Types

A HLA humanized mouse replaces the mouse HLA gene with the human ortholog for translational research and drug development. HLA transgenic models carry additional copies of the HLA gene for overexpression studies.

Humanized Mouse Models Transgenic Mouse Models Mouse Model Generation Services

Modifications available

Jump to catalog backed pages for HLA organized by modification type. Each URL is indexable and matches common search patterns.

HLA Humanized HLA Transgenic HLA Xenograft-Applicable

Related Gene Targets

hLAG3 hLAIR1

Breed this line with ingenious targeting laboratory

Send the HLA line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.

Mouse Models

Two paths. One scientific team.

Search 14,774+ study ready strains, or commission the exact knockout, knockin, or humanized model your program requires.

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HLA models ready to ship

Get a confirmed quote in 24 hours. All HLA models ship with full QC documentation, health certificates, and lifetime technical support.

HLAStudy ready strains in catalog

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Model generation

Need a knockout, knockin, or humanized line?

Specialized conventional and conditional knockouts
Knockins including point mutations, cDNA insertions, and epitope tags
Humanized models, including partial and full gene replacements
Targeted transgenesis in safe harbor loci
Inducible/reversible alleles using advanced recombinase techniques

The same U.S. scientific team designs and delivers your allele when it is not on the shelf. 2,800+ custom models generated since 1998. 100% germline transmission guarantee.

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