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HLA Xenograft-Applicable mouse models
Baseline HLA loss or humanization may change engraftment. Pilot cohorts de risk larger studies.
What HLA Xenograft-Applicable mouse models are available?
ingenious targeting laboratory offers 6 distinct HLA xenograft-applicable catalog mouse models. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| HLA-A11.1/B2M(2)/hPD-1/hPD-L1 | XA | Target-Humanized | DEVELOPING | XA 261693 | Inquire |
| The HLA-A11.1/B2M(2) (HU 241354) was crossed with hPD-1/hPD-L1(HU 00100) to generate HLA-A11.1/B2M(2)/hPD-1/hPD-L1 mice. | |||||
| HLA-A24.2/B2M(2)/hCD3EDG | XA | Target-Humanized | DEVELOPING | XA 261692 | Inquire |
| The HLA-A24.2/B2M(2) (HU 241352) was crossed with hCD3EDG(HU 220120) to generate HLA-A24.2/B2M(2)/hCD3EDG mice. | |||||
| HLA-A24.2/B2M(2)/hPD-1/hPD-L1 | XA | Target-Humanized | DEVELOPING | XA 261694 | Inquire |
| The HLA-A24.2/B2M(2) (HU 241352) was crossed with hPD-1/hPD-L1(HU 00100) to generate HLA-A24.2/B2M(2)/hPD-1/hPD-L1 mice. | |||||
| HLA-A2.1/B2M/hCD3EDG | XA | Target-Humanized | DEVELOPING | XA 261690 | Inquire |
| The HLA-A2.1/B2M (HU 241353) was crossed with hCD3EDG(HU 220120) to generate HLA-A2.1/B2M/hCD3EDG mice. | |||||
| HLA-A2.1/B2M/hIDO1/hPD-1/hPD-L1 | XA | Target-Humanized | LIVE | XA 260456 | Inquire |
| The hIDO1/HLA-A2.1/B2M (XA 252091) was crossed with hPD-1/hPD-L1(HU 00100) to generate hIDO1/HLA-A2.1/B2M/hPD-1/hPD-L1 mice. | |||||
| HLA-A11.1/B2M(2)/hCD3EDG | XA | Target-Humanized | DEVELOPING | XA 261691 | Inquire |
| The HLA-A11.1/B2M(2) (HU 241354) was crossed with hCD3EDG(HU 220120) to generate HLA-A11.1/B2M(2)/hCD3EDG mice. | |||||
Why this approach
We help teams pick alleles that match the experimental question, the organ system, and future breeding plans. For your target tissue centric work, Cre specificity, flox placement, and baseline controls matter as much as the gene edit itself.
Pricing and quotes
The HLA Xenograft-Applicable lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a HLA allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What HLA Xenograft-Applicable mouse models are available?
When HLA Xenograft-Applicable lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is HLA knockout embryonic lethal in mice?
It depends on background and allele design. Some HLA germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live HLA animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for HLA?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Citations
- Loss-of-function OGFRL1 variants identified in autosomal recessive cherubism families
- Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates Skeletal Muscle Myogenesis through the E2F1-DP1 Complex.
- Rgnef (p190RhoGEF) knockout inhibits RhoA activity, focal adhesion establishment, and cell motility downstream of integrins.
- Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.
Breed this line with ITL
Send the HLA Xenograft-Applicable line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.