Skip to main content

HLA Humanized mouse models

These models bridge mouse genetics with translational readouts on human biology at the HLA locus.

Request a quote

Catalog table

Knockin and humanized formats preserve regulatory context at the endogenous locus. For your target tissue focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.

Knockin and humanized formats preserve regulatory context at the endogenous locus. For liver focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.

ModelTypeCategoryAvailabilityCatalog #Action
HLA-B39.1/B2MHumanizedTarget humanized miceF0 liveHU 252702Inquire
HLA-B7.2/B2MHumanizedTarget humanized miceF0 liveHU 252701Inquire
HLA-B58.1/B2MHumanizedTarget humanized miceF0 liveHU 252700Inquire
HLA-B40.1/B2MHumanizedTarget humanized miceF0 liveHU 252699Inquire
HLA-DPA1/HLA-DPB1HumanizedTarget humanized miceliveHU 234679Inquire
HLA-DR1 (HLA-DRA*0101/HLA-DRB1*0101)HumanizedTarget humanized miceF0 liveHU 241520Inquire
HLA-DQ8HumanizedTarget humanized miceliveHU 240843Inquire
HLA-G/B2MHumanizedTarget humanized micesperm cryopreservationHU 241967Inquire
HLA-A11.1/B2M(2)HumanizedTarget humanized miceliveHU 241354Inquire
HLA-A2.1/B2MHumanizedTarget humanized miceliveHU 241353Inquire
HLA-A24.2/B2M(2)HumanizedTarget humanized miceliveHU 241352Inquire
HLA-A1.1/B2MHumanizedTarget humanized miceliveHU 241351Inquire
HLA-A3.1/B2MHumanizedTarget humanized miceliveHU 250773Inquire
HLA-A2.22/B2MHumanizedTarget humanized micesperm cryopreservationHU 210010Inquire
HLA-A24.2/B2M(M-NSG)HumanizedTarget humanized mice, Immunodeficient miceF0 liveHU 252347Inquire
HLA-A11.1/B2M(M-NSG)HumanizedTarget humanized mice, Immunodeficient miceF0 liveHU 252346Inquire
HLA-A3.1/B2M(M-NSG)HumanizedTarget humanized mice, Immunodeficient miceF0 liveHU 252345Inquire
HLA-A2.1/B2M(M-NSG)(2)HumanizedTarget humanized mice, Immunodeficient miceliveHU 241683Inquire

Why this approach

Knockin and humanized formats preserve regulatory context at the endogenous locus. For your target tissue focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.

Knockin and humanized formats preserve regulatory context at the endogenous locus. For liver focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.

Build timeline and pricing

Typical custom projects target study ready cohorts near twenty six weeks from contract start when breeding is direct. Quotes return in about twenty four hours with milestones, pricing, and options for cryo or live dispatch.

Open the request quote form

FAQ

How long does a HLA humanized project take?

Most custom humanized projects run near twenty six weeks from contract activation to study ready animals when breeding is straightforward. Complex humanization or multi allele stacks can add time. We return detailed quotes within about twenty four hours so you can align cohort start dates with grant or IND milestones.

Is HLA knockout embryonic lethal in mice?

Lethality depends on genetic background and exact allele design. Some HLA germline knockouts are viable, others require conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null approaches before you commit.

Which Cre driver is best for experiments?

Driver choice depends on onset timing, recombination efficiency, and known leak patterns. We map your organ and cell type to a short list of proven Cre lines, then discuss reporter crosses and controls. We prioritize drivers with strong community validation for your tissue.

Do you ship live HLA animals?

When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a custom project with cryo or live dispatch options depending on cohort timing and geography.

How do I request a quote for HLA?

Use the catalog inquire buttons or the request quote form with your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.

Related models and routes

All HLA models
hLAG3 HumanizedhLAG3(BALB/c) HumanizedhLAG3/hCTLA HumanizedhLAIR1 HumanizedhLAIR1/hPD Humanized

Citations