HLA Humanized mouse models
These models bridge mouse genetics with translational readouts on human biology at the HLA locus.
Catalog table
Knockin and humanized formats preserve regulatory context at the endogenous locus. For your target tissue focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.
Knockin and humanized formats preserve regulatory context at the endogenous locus. For liver focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| HLA-B39.1/B2M | Humanized | Target humanized mice | In production — inquire | HU 252702 | Inquire |
| HLA-B7.2/B2M | Humanized | Target humanized mice | In production — inquire | HU 252701 | Inquire |
| HLA-B58.1/B2M | Humanized | Target humanized mice | In production — inquire | HU 252700 | Inquire |
| HLA-B40.1/B2M | Humanized | Target humanized mice | In production — inquire | HU 252699 | Inquire |
| HLA-DPA1/HLA-DPB1 | Humanized | Target humanized mice | live | HU 234679 | Inquire |
| HLA-DR1 (HLA-DRA*0101/HLA-DRB1*0101) | Humanized | Target humanized mice | In production — inquire | HU 241520 | Inquire |
| HLA-DQ8 | Humanized | Target humanized mice | live | HU 240843 | Inquire |
| HLA-G/B2M | Humanized | Target humanized mice | sperm cryopreservation | HU 241967 | Inquire |
| HLA-A11.1/B2M(2) | Humanized | Target humanized mice | live | HU 241354 | Inquire |
| HLA-A2.1/B2M | Humanized | Target humanized mice | live | HU 241353 | Inquire |
| HLA-A24.2/B2M(2) | Humanized | Target humanized mice | live | HU 241352 | Inquire |
| HLA-A1.1/B2M | Humanized | Target humanized mice | live | HU 241351 | Inquire |
| HLA-A3.1/B2M | Humanized | Target humanized mice | live | HU 250773 | Inquire |
| HLA-A2.22/B2M | Humanized | Target humanized mice | sperm cryopreservation | HU 210010 | Inquire |
| HLA-A24.2/B2M(M-NSG) | Humanized | Target humanized mice, Immunodeficient mice | In production — inquire | HU 252347 | Inquire |
| HLA-A11.1/B2M(M-NSG) | Humanized | Target humanized mice, Immunodeficient mice | In production — inquire | HU 252346 | Inquire |
| HLA-A3.1/B2M(M-NSG) | Humanized | Target humanized mice, Immunodeficient mice | In production — inquire | HU 252345 | Inquire |
| HLA-A2.1/B2M(M-NSG)(2) | Humanized | Target humanized mice, Immunodeficient mice | live | HU 241683 | Inquire |
Why this approach
Knockin and humanized formats preserve regulatory context at the endogenous locus. For your target tissue focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.
Knockin and humanized formats preserve regulatory context at the endogenous locus. For liver focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.
Pricing and quotes
The HLA Humanized lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a HLA allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
Is HLA knockout embryonic lethal in mice?
Lethality depends on genetic background and exact allele design. Some HLA germline knockouts are viable, others require conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null approaches before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak patterns. We map your organ and cell type to a short list of proven Cre lines, then discuss reporter crosses and controls. We prioritize drivers with strong community validation for your tissue.
Do you ship live HLA animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a model generation project with cryo or live dispatch options depending on cohort timing and geography.
How do I request a quote for HLA?
Use the catalog inquire buttons or the request quote form with your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.