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HLA Humanized mouse models
These models bridge mouse genetics with translational readouts on human biology at the HLA locus.
What HLA Humanized mouse models are available?
ingenious targeting laboratory offers 31 distinct HLA humanized catalog mouse models. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| HLA-DR4 (HLA-DRA*0101/HLA-DRB1*0401,Balb/c) | HU | Target-Humanized | DEVELOPING | HU 263065 | Inquire |
| This mouse model was derived from the existing HLA-DRA*0101 (BALB/c) (HU 263059) strain. Further humanization modification of the H2-Ab1 gene was carried out through homologous recombination technology. | |||||
| HLA-DR1 (HLA-DRA*0101/HLA-DRB1*0101,Balb/c) | HU | Target-Humanized | DEVELOPING | HU 263064 | Inquire |
| This mouse model was derived from the existing HLA-DRA*0101 (BALB/c) (HU 263059) strain. Through homologous recombination technology, the H2-Ab1 gene was further modified for humanization. | |||||
| HLA-E1.3/B2M(2) | HU | Target-Humanized | IN PRODUCTION | HU 261706 | Inquire |
| The endogenous mouse B2m gene was replaced by human B2M gene. | |||||
| HLA-A11.1/B2M(2) | HU | Target-Humanized | LIVE | HU 241354 | Inquire |
| The endogenous mouse B2m gene was replaced by hB2M-linker-HLA-A*1101/H2-D1 gene. | |||||
| HLA-A2.1/B2M | HU | Target-Humanized | LIVE | HU 241353 | Inquire |
| The endogenous mouse B2m gene was replaced by hB2M-linker-HLA-A*0201/H2-D1 gene. | |||||
| HLA-A24.2/B2M(2) | HU | Target-Humanized | LIVE | HU 241352 | Inquire |
| The endogenous mouse B2m gene was replaced by hB2M-linker-HLA-A*2402/H2-D1 gene. | |||||
| HLA-A1.1/B2M | HU | Target-Humanized | LIVE | HU 241351 | Inquire |
| The endogenous mouse B2m gene was replaced by hB2M-linker-HLA-A*0101/H2-D1 gene. | |||||
| HLA-A3.1/B2M | HU | Target-Humanized | LIVE | HU 250773 | Inquire |
| The endogenous mouse B2m gene was replaced by hB2M-linker-HLA-A*0301/H2-D1. | |||||
| HLA-A2.22/B2M | HU | Target-Humanized | SPERM | HU 210010 | Inquire |
| The endogenous mice H2-D1 gene was replaced by human B2M/HLA-A2 gene | |||||
| HLA-A2.22 | HU | Target-Humanized | EMBRYO | HU 204988 | Inquire |
| The endogenous mice H2-D1 gene was replaced by human HLA-A2 gene. | |||||
| HLA-B27.5/B2M | HU | Target-Humanized | IN PRODUCTION | HU 261003 | Inquire |
| The endogenous mouse B2m gene was replaced by human B2M gene. | |||||
| HLA-B27.5/B2M(BALB/c) | HU | Target-Humanized | IN PRODUCTION | HU 260633 | Inquire |
| The endogenous mouse B2m gene was replaced by human B2M gene. | |||||
| HLA-A2.1/B2M(BALB/c) | HU | Target-Humanized | IN PRODUCTION | HU 260895 | Inquire |
| The endogenous mouse B2m gene was replaced by human B2M gene. | |||||
| HLA-A11.1/B2M(BALB/c) | HU | Target-Humanized | IN PRODUCTION | HU 260893 | Inquire |
| The endogenous mouse B2m gene was replaced by human B2M gene. | |||||
| HLA-A24.2/B2M(BALB/c) | HU | Target-Humanized | IN PRODUCTION | HU 260892 | Inquire |
| The endogenous mouse B2m gene was replaced by human B2M gene. | |||||
| HLA-A11.1/B2M(V1) | HU | Target-Humanized | LIVE | HU 254021 | Inquire |
| The endogenous mouse H2-K1 gene was replaced by human HLA-A gene. | |||||
| HLA-A24.2/B2M(V1) | HU | Target-Humanized | IN PRODUCTION | HU 254020 | Inquire |
| The endogenous mouse H2-D1 gene was replaced by human HLA-A gene. | |||||
| HLA-A2.1/B2M(V1) | HU | Target-Humanized | LIVE | HU 253999 | Inquire |
| The endogenous mouse B2m gene was replaced by human B2M gene. | |||||
| HLA-B39.1/B2M | HU | Target-Humanized | LIVE | HU 252702 | Inquire |
| The endogenous mouse B2m gene was replaced by human HLA-B gene. | |||||
| HLA-B7.2/B2M | HU | Target-Humanized | LIVE | HU 252701 | Inquire |
| The endogenous mouse B2m gene was replaced by human HLA-B gene. | |||||
| HLA-B58.1/B2M | HU | Target-Humanized | IN PRODUCTION | HU 252700 | Inquire |
| The endogenous mouse B2m gene was replaced by human HLA-B gene. | |||||
| HLA-B40.1/B2M | HU | Target-Humanized | LIVE | HU 252699 | Inquire |
| The endogenous mouse B2m gene was replaced by human HLA-B gene. | |||||
| HLA-A24.2/B2M(M-NSG) | HU | Target-Humanized, Immunodeficient | DEVELOPING | HU 252347 | Inquire |
| The endogenous mouse B2m gene was replaced by hB2M-linker-HLA-A*2402/H2-D1 gene. | |||||
| HLA-A11.1/B2M(M-NSG) | HU | Target-Humanized, Immunodeficient | LIVE | HU 252346 | Inquire |
| The endogenous mouse B2m gene was replaced by hB2M-linker-HLA-A*1101/H2-D1 gene. | |||||
| HLA-A3.1/B2M(M-NSG) | HU | Target-Humanized, Immunodeficient | LIVE | HU 252345 | Inquire |
| The endogenous mouse B2m gene was replaced by hB2M-linker-HLA-A*0301/H2-D1 gene. | |||||
| HLA-DR1 (HLA-DRA*0101/HLA-DRB1*0101) | HU | Target-Humanized | DEVELOPING | HU 241520 | Inquire |
| The endogenous mouse H2-Aa gene was replaced by human HLA-DRA gene.The endogenous mouse H2-Ab1 gene was replaced by human HLA-DRB1*0101 gene. | |||||
| HLA-DR4 (HLA-DRA*0101/HLA-DRB1*0401) | HU | Target-Humanized | DEVELOPING | HU 241519 | Inquire |
| The endogenous mouse H2-Aa gene was replaced by human HLA-DRA*0101 gene.The endogenous mouse H2-Ab1 gene was replaced by human HLA-DRB1*0401 gene. | |||||
| HLA-DQ8 | HU | Target-Humanized | LIVE | HU 240843 | Inquire |
| The endogenous mouse H2-Aa gene was replaced by human HLA-DQA1*0301 gene. The endogenous mouse H2-Ab1 gene was replaced by human HLA-DQB1*0302 gene. | |||||
| HLA-DPA1/HLA-DPB1 | HU | Target-Humanized | LIVE | HU 234679 | Inquire |
| The endogenous mouse H2-Aa gene was replaced by human HLA-DPA1*02:02 gene. The endogenous mouse H2-Ab1 gene was replaced by human HLA-DPB1*03:01 gene. | |||||
| HLA-A2.1/B2M(M-NSG)(2) | HU | Target-Humanized, Immunodeficient | LIVE | HU 241683 | Inquire |
| The endogenous mouse B2m gene was replaced by hB2M/HLA-A2.1/H2-D1 gene. | |||||
| HLA-G/B2M | HU | Target-Humanized | SPERM | HU 241967 | Inquire |
| The endogenous mouse B2m gene was replaced by human B2M/HLA-G gene. | |||||
Why this approach
Knockin and humanized formats keep regulatory context at the endogenous locus. For your target tissue focused programs, that matters when expression timing, splice isoforms, or allele dosage drive biology. Random integration transgenics can still help, but targeted alleles usually give cleaner pharmacology readouts.
Pricing and quotes
The HLA Humanized lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a HLA allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What HLA Humanized mouse models are available?
When HLA Humanized lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is HLA knockout embryonic lethal in mice?
It depends on background and allele design. Some HLA germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live HLA animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for HLA?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Citations
- Loss-of-function OGFRL1 variants identified in autosomal recessive cherubism families
- Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates Skeletal Muscle Myogenesis through the E2F1-DP1 Complex.
- Rgnef (p190RhoGEF) knockout inhibits RhoA activity, focal adhesion establishment, and cell motility downstream of integrins.
- Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.
Breed this line with ingenious targeting laboratory
Send the HLA Humanized line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.